ArticleAlpha psychiatry2025
Gender Differences in Prevalence and Clinical Correlates of Initial-Treatment and Drug-Naïve Bipolar Disorder Patients With Metabolic Syndrome: A Cross-Sectional Study.
Article in Alpha psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Bipolar disorder (BD) has been studied extensively. However, no studies have investigated gender differences in the prevalence of metabolic syndrome (MetS) in initial-treatment and drug-naïve (ITDN) patients with BD. Therefore, the aim of this study was to investigate gender differences and correlates of MetS in ITDN patients with BD. Methods: A cross-sectional study of 671 ITDN patients with BD was conducted. Demographic and clinical data were collected. Patients underwent routine serum tests including fasting blood glucose, lipid profile, thyroid function and prolactin tests. Manic, depressive and psychotic symptoms and severity of illness were measured using the Youth Mania Rating Scale (YMRS), the Hamilton Depression Scale (HAMD), the Positive Symptom Scale of the Positive and Negative Symptom Scale (PSS, items P1-P7) and the Clinical Global Impression Scale-Severity of Illness (CGI-SI), respectively. Results: There was no gender difference in the prevalence of MetS in ITDN patients with BD. Two-way analysis of covariance (ANCOVA) revealed an interaction effect between MetS status and gender for total thyroxine (TT Conclusion: TT
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