ArticleFrontiers in veterinary science2025
Untargeted metabolomic analysis of dietary rumen-protected choline supplementation in fattening lambs.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Blood-based biomarkers of protein digestibility, utilization, and nitrogen excretion in animals: Concepts, evidence, and applications.Veterinary and animal science · 2026Review
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Authors and funding
4 authors.
Funding
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Abstract
Introduction: Choline is an essential nutrient that plays a key role in lipid metabolism and growth performance in livestock. Methods: This study investigated the effects of rumen-protected choline (RPC) supplementation on serum metabolite profiles in fattening lambs. Twenty 3-month-old hybrid rams (Small-Tailed Han × Northeast Fine-Wool; initial body weight: 15.3 ± 1.8 kg) were randomly assigned to two groups ( Results: A wide range of metabolites were identified, including benzenoids, lipids and lipid-like molecules, nucleosides and nucleotides, organic acids, and derivatives. Pathway analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) revealed involvement in lipid, amino acid, vitamin, and carbohydrate metabolism. Partial least squares-discriminant analysis (PLS-DA) showed clear separation between CON and RPC groups. Triacylglycerol, L-methionine, plasmenylcholine, taurocholate, 1-acyl-sn-glycero-3-phosphoethanolamine, and 1-acyl-sn-glycero-3-phosphocholine were identified as potential bio markers associated with increased hot carcass weight (HCW) and slaughter rate. Discussion: RPC supplementation significantly modulated the serum metabolome, enhancing HCW and slaughter rate, likely via lipid, amino acid, and energy metabolism pathways.
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