ArticleUrology case reports2025
Bilateral testicular atrophy and hypogonadism induced by paratesticular leiomyosarcoma and untreated cryptorchidism.
Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Paratesticular leiomyosarcomas are rare low-grade malignancies from smooth muscle, presenting as painless scrotal masses in middle-aged men. This case describes a 48-year-old with a left-sided tumor and contralateral cryptorchidism, leading to bilateral testicular compromise and hypogonadism. He presented with asymptomatic left scrotal enlargement; examination revealed a 7-cm left mass and atrophic right inguinal testis. Labs showed normal tumor markers but primary hypogonadism. Imaging confirmed no metastasis. Bilateral orchiectomy yielded grade 1 pT1 leiomyosarcoma (positive for smooth muscle actin, desmin, vimentin) on the left and atrophy on the right. At 2-year follow-up, he remains disease-free on testosterone replacement.
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