ArticleFrontiers in aging2025
Age-related lung structure changes by quantitative assessment: a cross-sectional study in a Chinese male cohort.
Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study aims to investigate age-related alterations of lung structure. Methods: We retrospectively collected 928 male subjects from an annual lung nodule screening cohort. The quantitative parameters included lung volume (LV), mean lesion density (MLD), emphysema indexes (LAA-910, LAA-910%, LAA-950 and LAA-950%), number of bronchi (NB) and volume of bronchi (VB), as well as ratio of airway to the lung (ALR). The quantitative parameters were calculated for total lung, right lung, left lung, and the individual lobes. Results: LV and VB peaked in the group of 51-60 years-old and 61-70 years-old, respectively. MLD decreased with age, while LAA-910, LAA-950, LAA-910%, LAA-950%, and ALR all showed an increasing trend with age. LV, NB, and VB of the right lung were larger than those of the left lung, while MLD, LAA-950, LAA-950%, and ALR of the right lung were lower than those of the left lung ( Conclusion: Lung aging is not a linear process, and the lung structural alterations in the upper and lower lobes exhibit significant heterogeneity.
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