ArticleFrontiers in human neuroscience2025
Clinical study of wearable low-intensity pulsed ultrasound treatment in the improvement of executive function in obesity (the SLITE trial): protocol for a single -centre, double-blind, randomized controlled trial.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Low-Intensity Pulsed Ultrasound Alleviation of LPS-Induced Depression-Like Behavior via Microglial P2X4R Inhibition and BDNF/TrkB Pathway Activation.CNS neuroscience & therapeutics · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Introduction: Obesity is a global health crisis associated with significant physical and cognitive impairments, particularly in executive function. Impaired executive function exacerbates unhealthy eating behaviors and hinders effective weight management. Non-invasive neuromodulation techniques like transcranial direct current stimulation and transcranial magnetic stimulation have demonstrated potential in improving executive function and assisting in weight reduction but face limitations in accessibility and efficacy. Low-intensity pulsed ultrasound (LIPUS) represents an emerging neuromodulation technique distinguished by its non-invasive application and superior spatial resolution, facilitating targeted modulation of cortical activity and neural excitability with high precision. This study aims to explore the efficacy of LIPUS on executive function in obesity. Methods and analysis: This study adopts a prospective, single-center, double-blind, randomized controlled design. A total of 44 participants diagnosed with obesity (BMI ≥ 28 kg/m Discussion: This trial will be the first to evaluate LIPUS for enhancing executive function in individuals with obesity. By combining wearable ultrasound technology with neuroimaging assessments, the study is expected to provide novel evidence for the neuromodulatory role of LIPUS. The results may support the development of innovative, non-invasive strategies for obesity management and inform future clinical applications.
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