ArticleQuantitative imaging in medicine and surgery2025
Carotid intraplaque neovascularization for predicting ischemic cerebrovascular events in patients with hypertension.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Atherosclerotic plaque distribution and characteristics in young patients with stroke/transient ischemic attack: insights from MR vessel wall imaging and comparison with older counterparts.Quantitative imaging in medicine and surgery · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with hypertension are prone to developing carotid atherosclerotic plaques, and unstable plaques are a key contributor to ischemic cerebrovascular events (ICEs), including transient ischemic attacks (TIAs) and ischemic strokes. Intraplaque neovascularization (IPN), the formation of microvessels within plaques, is a recognized marker of plaque vulnerability. This study aimed to evaluate the association between IPN in carotid plaques and the risk of ICEs in older adult patients with hypertension. Methods: This retrospective cohort study included 438 patients with hypertension aged ≥60 years. Carotid plaques were assessed with superb microvascular imaging (SMI), and IPN was graded from 0 (none) to 3 (severe). Patients were followed up for 3 years to track the incidence of ICEs. Logistic regression models were used to analyze the association between IPN grade and ICE risk, with adjustments made for demographic and cardiovascular risk factors. Results: Among the 314 patients with carotid plaques, 113 (36.0%) experienced ICEs during follow-up. The incidence of ICEs increased progressively with IPN severity: 15.2% for grade 0, 37.3% for grade 1, 50.5% for grade 2, and 51.2% for grade 3. Compared to that in patients with IPN grade 0, the odds of ICEs were significantly higher in patients with IPN grade 2 [odds ratio (OR) =3.73; P<0.01] and grade 3 (OR =5.14; P<0.01). IPN grade >1 was significantly associated with increased ICE risk (P<0.05). After adjustments were made for age, sex, smoking, diabetes, and hyperlipidemia, IPN remained an independent predictor of ICEs [adjusted OR =1.87; 95% confidence interval (CI): 1.12-3.14; P=0.03]. Conclusions: Carotid IPN, as assessed by SMI, is independently associated with an elevated risk of ICEs in older adult patients with hypertension. IPN grading may serve as a useful and noninvasive marker for cerebrovascular risk stratification in this population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.