ArticleQuantitative imaging in medicine and surgery2025
Comparative analysis of the geometric morphology and local hemodynamics of small and medium intracranial aneurysms: a two-center retrospective study in a Chinese Han population.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Possible hemodynamic mechanisms in the size change of cerebral aneurysms: an exploratory study.Quantitative imaging in medicine and surgery · 2026Article
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15 authors.
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Abstract
Background: Small (<4 mm) and medium (≥4 and <15 mm) intracranial aneurysms (IAs) account for the majority of lesions detected on routine cerebrovascular imaging, yet their true rupture propensity and mechanistic pathways remain controversial, particularly in Asian populations. Emerging evidence indicates that geometry-dependent hemodynamic disturbances may modulate rupture risk, but size-specific patterns have not been systematically compared. Therefore, we aimed to compare the clinical, geometric, and hemodynamic characteristics of small and medium IAs and to clarify the rupture-related mechanisms. Methods: We retrospectively reviewed computed tomography angiography (CTA) and digital subtraction angiography (DSA) in 214 patients with ruptured or unruptured IAs. Geometric parameters [location, dimensions, aspect ratio (AR), size ratio (SR), bottleneck ratio (BN), height-to-width ratio (HWR), and incidence angle] and key hemodynamic metrics [oscillatory shear index (OSI), relative residence time, time-averaged wall shear stress (TAWSS), time-averaged wall shear stress gradient (TAWSSG), and aneurysm formation indicator (AFI)] were calculated. Receiver operating characteristic analysis determined the aneurysm size threshold associated with rupture. Results: Medium aneurysms ruptured more frequently than did small aneurysms (67.4% Conclusions: Small and medium IAs exhibit distinct geometric and hemodynamic profiles linked to rupture. Prospective longitudinal studies are needed to confirm these associations and clarify causal pathways.
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