ArticleQuantitative imaging in medicine and surgery2025
Early-stage fusion and bone morphology process in anterior cervical discectomy and fusion: a comparison of autografts and allografts via quantitative computed tomography-based three-dimensional reconstruction.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Impact of perioperative GLP-1 agonist use on pseudarthrosis rates following single-level anterior cervical discectomy and fusion: a propensity-matched cohort study.Journal of spine surgery (Hong Kong) · 2026Article
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10 authors.
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Abstract
Background: Anterior cervical discectomy and fusion (ACDF) is a standard surgical procedure for treating degenerative cervical disc diseases. However, the differences between autograft and allografts in terms of early-stage fusion and bone morphology remain largely unclear. This study aimed to provide a comprehensive analysis of the fusion process via quantitative computed tomography (CT)-based three-dimensional (3D) reconstruction, focusing on the differences between autografts and allografts and their impact on clinical outcomes. Methods: A retrospective analysis was conducted on 134 patients who underwent single- or two-level ACDF with polyetheretherketone (PEEK) cages filled with either autografts (n=80) or allografts (n=54). Fusion volume and osteogenic morphology were assessed at 3, 6, 12, and 24 months postoperatively via CT-based 3D reconstruction. Fusion morphology was classified into stalactite, hourglass, and columnar patterns. Clinical outcomes were evaluated with the neck pain visual analog scale (VAS) and modified Japanese Orthopaedic Association (mJOA) scores, while radiographic parameters included cervical sagittal vertical axis (cSVA), C2-7 lordosis, segmental height, and subsidence. Results: At 3 and 6 months, the autograft group, as compared to the allograft group, exhibited significantly higher fusion volumes (3 months: the autograft group 185.04±92.67 mm Conclusions: Quantitative CT-based 3D reconstruction offers a highly precise and dynamic approach for assessing bone fusion in ACDF, enabling detailed visualization of fusion morphology and volume over time. These findings indicate that autografts promote earlier and more robust osteogenesis, leading to superior early clinical outcomes. These results emphasize the importance of graft selection and suggest that advanced 3D imaging techniques should be integrated into clinical practice to enhance fusion evaluation and optimize patient recovery.
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