ArticleQuantitative imaging in medicine and surgery2025
Hemodialysis and its effects on glymphatic system function in end-stage kidney disease patients.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Chronic kidney disease and cognitive decline: choroid plexus remodeling, glymphatic dysfunction, and alzheimer biomarker interpretation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
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8 authors.
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Abstract
Background: The glymphatic system, responsible for clearing metabolic waste from the brain, may be affected in patients with end-stage kidney disease (ESKD), potentially impacting brain health. This study investigates the effects of hemodialysis on glymphatic function in ESKD patients. Methods: This prospective study enrolled ESKD patients along with age- and sex-matched healthy controls (HCs). Each ESKD patient underwent magnetic resonance imaging (MRI) scans before and after a single hemodialysis session to obtain diffusion tensor imaging (DTI) data. HCs underwent a single MRI scan. The analysis along the perivascular space (ALPS) index was calculated using DTI-ALPS to indirectly assess changes in glymphatic system function pre- and post-hemodialysis in ESKD patients and to compare pre-hemodialysis with HCs. Additionally, correlations between the ALPS index and clinical indicators were assessed to explore potential links between glymphatic and kidney function. Results: A total of 25 ESKD patients (mean age 49.80±13.01 years; 14 males) and 27 HCs (mean age 48.67±10.16 years; 12 males) were analyzed. After hemodialysis, ESKD patients showed increased calcium (2.09±0.28 Conclusions: ESKD patients exhibited a significantly lower ALPS index compared with HCs, indicating altered perivascular diffusion patterns. No significant changes in the ALPS index were detected after a single hemodialysis session. As the ALPS index is an indirect marker, further research is needed to clarify its relationship with glymphatic function in kidney disease.
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