ArticleKidney medicine2025
A Systematic Review Comparing the Prognostic Role of eGFR According to CKD-EPI and Older Age Validated Equations in Older Adults.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Rationale & Objective: Assessing the clinical relevance of reduced estimated glomerular filtration rate (eGFR) in older adults is challenging because GFR naturally declines with age and not all equations, including the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, have been validated for use in older adults. This systematic review compared the association between eGFR and health outcomes in older adults using eGFR equations validated for older age and the CKD-EPI eGFR. Study Design: Prognostic factor systematic review and meta-analysis. Setting & Study Populations: Community-dwelling adults aged ≥ 65 years. Selection Criteria for Studies: Studies using CKD-EPI and at least one of Berlin Initiative Study 1, Berlin Initiative Study 2, European Kidney Function Consortium, Full Age Spectrum, and Revised Lund-Malmo equations to calculate eGFR in association with mortality, cardiovascular outcomes, hospitalizations, or kidney failure. This study was registered on PROSPERO (ID: CRD42022359839). Analytical Approach: Meta-analysis was undertaken using random-effects models. Results: Thirteen studies met inclusion criteria with a total of 102,893 participants. The pooled mean age was 80 years (IQR: 76-84), and baseline CKD-EPI Limitations: Limited number of studies and overall low quality of data. Conclusions: There was no evidence that the association between eGFR and mortality in older adults differed between CKD-EPI and eGFR equations validated for older age. Studies comparing eGFR equations as predictors of hospitalizations, cardiovascular outcomes, or kidney failure were lacking.
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