ArticleFrontiers in immunology2025
Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The COVID-19 pandemic, caused by SARS-CoV-2, represents one of the most profound global public health challenges in modern history. While T cell immunity is crucial for viral clearance, the dynamics of the T cell receptor (TCR) repertoire during reinfection remain poorly understood. This study sought to characterize the TCR repertoire in peripheral blood T cells from healthy convalescent individuals (HC), patients with primary SARS-CoV-2 infection (PI), and reinfected individuals (RI), aiming to identify distinct TCR signatures linked to susceptibility or protection against reinfection. We enrolled 48 age- and sex-matched participants (18 PI, 18 RI, 12 HC), collecting blood samples during acute infection (PI/RI) or convalescence (HC). Deep TCRα/β sequencing was performed using the SMARTer Human TCR Profiling Kit with unique molecular identifiers (UMIs), followed by analysis of TCR repertoire diversity, clonal expansion, V(D)J gene usage, and CDR3 characteristics. Compared to HC, both PI and RI groups exhibited significantly reduced TCR diversity (
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