ArticleFrontiers in immunology2025
Metatranscriptomic analysis of the gut virome in Muscovy ducks reveals a novel duck reovirus potentially associated with hepatic and splenic hemorrhage.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Comparative analysis of gut virome signatures between ducks raised in aquatic and dryland environments.Poultry science · 2026Article
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Authors and funding
16 authors.
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Abstract
Introduction: Ducks rank among the most important sources of animal protein globally, yet hepatic and splenic hemorrhage and necrosis in Muscovy ducks present a critical challenge to the poultry industry. The causes behind such diseases are often multifaceted, involving both established and newly emerging pathogens. Methods: In this study, we leveraged metatranscriptomic sequencing to profile the intestinal viral communities of healthy and diseased Muscovy ducks from a Guangdong Province farm that experienced a hepatic and splenic hemorrhage in June 2024. Results: Our findings revealed marked differences in viral community profiles between the two groups, with the diseased cohort exhibiting higher α-diversity. Taxonomic analyses across multiple levels uncovered significant variations in viral composition, including shifts in phylums like Uroviricota and families such as Demerecviridae. At the genus and species levels, several bacteriophages and eukaryotic viruses displayed differential abundance. Notably, Avian orthoreovirus was detected exclusively in diseased ducks, with a specific novel duck reovirus (NDRV) validated via RT-qPCR as a potential contributor to hepatic and splenic pathogenesis. In contrast, known pathogens such as Duck hepatitis A virus (DHAV) and Fowl adenovirus serotype 4 (FAdV-4) were not detected. Discussion: This study constitutes the first comprehensive analysis of the Muscovy duck gut virome, highlighting NDRV as a potential causative agent and emphasizing the utility of metatranscriptomics in pathogen discovery.
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