Evidence map›Paper›PMID 41208999›Full record

ArticleFrontiers in immunology2025

Micro-geographic variation in antigenic diversity of PfEBA-175 region II in asymptomatic

Jadidan Hada Syahada, Wang-Jong Lee, Hojong Jun, Johnsy Mary Louis, Fadhila Fitriana, Fauzi Muh, Feng Lu, Md Atique Ahmed, Sunghun Na, Wanjoo Chun and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jadidan Hada SyahadaDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Wang-Jong LeeDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Hojong JunDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Johnsy Mary LouisDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Fadhila FitrianaDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Fauzi MuhDepartment of Epidemiology and Tropical Diseases, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia.
Feng LuDepartment of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, China.
Md Atique AhmedMalaria Division, Indian Council of Medical Research (ICMR)-Regional Medical Research Centre, Dibrugarh, Assam, India.
Sunghun NaDepartment of Obstetrics and Gynecology, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Wanjoo ChunDepartment of Pharmacology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Won Sun ParkDepartment of Physiology, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Bo-Young JeonDepartment of Biomedical Laboratory Science, College of Software and Digital Healthcare Convergence, Yonsei University, Wonju, Republic of Korea.
Eun-Teak HanDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Jim ToddDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Alphaxard ManjuranoDepartment of Parasitic Diseases, National Institute for Medical Research, Dar es Salaam, Tanzania.
Winifrida KidimaDepartment of Zoology, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, Tanzania.
Ernest MazigoDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Se Jin LeeDepartment of Obstetrics and Gynecology, Kangwon National University Hospital, Chuncheon, Republic of Korea.
Jin-Hee HanDepartment of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malaria remains a major public health burden, and the development of effective blood-stage vaccines is complicated by extensive antigenic variation in Methods: We examined the genetic diversity and antigenicity of PfEBA-175 region II (RII) in 172 asymptomatic Results: Sequence analysis revealed high nucleotide diversity (π = 0.00359 ± 0.00012), with evidence of adaptive evolution driven by immune pressure (d Conclusion: Despite substantial polymorphism, the glycan-binding residues of PfEBA-175 RII remain conserved, and its high antigenicity across diverse geographic and demographic contexts supports its continued evaluation as a blood-stage vaccine candidate. These findings highlight the importance of accounting for naturally occurring antigenic variation in malaria vaccine development.

Indexed as

Antigenic VariationAntigens, ProtozoanMalaria, FalciparumPlasmodium falciparumProtozoan ProteinsAdolescentAdultAntibodies, ProtozoanAsymptomatic InfectionsChildChild, PreschoolFemaleGenetic VariationHumansMaleMiddle AgedAntibodies, ProtozoanAntigens, Protozoanerythrocyte-binding antigen 175, PlasmodiumProtozoan Proteinsantigenicityblood-stage malaria vaccinegenetic diversityPfEBA-175Plasmodium falciparum

Identifiers

PMID41208999
PMCPMC12592157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.