Evidence map›Paper›PMID 41208992›Full record

ArticleFrontiers in immunology2025

Establishment of prognostic signature based on neutrophil extracellular traps-related genes in acute myeloid leukemia: a bioinformatics analysis.

Zhenglei Shen, Jingying Zhu, Ni Luo, Lei Feng, Heng Yue, Liying Song, Kunmei Liu, Huaxian Li, Honghua Cao, Yeying Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhenglei Shen *Department of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Jingying Zhu *Department of Head and Neck Thyroid Surgery Department, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Ni LuoDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Lei FengDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Heng YueDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Liying SongDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Kunmei LiuDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Huaxian LiDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Honghua CaoDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Yeying ZhouDepartment of Hematology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.
Yasar Mehmood YousafzaiInstitute of Pathology and Diagnostic Medicine Khyber Medical University, Peshawar, Pakistan.
Zia AsadMolecular Biologist Public Health Reference Laboratory, Peshawar, Pakistan.
Youyu QiuRadiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Shiwen ZhangDepartment of Head and Neck Thyroid Surgery Department, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute myeloid leukemia (AML) is a hematological malignancy with a high incidence of febrile neutropenia during the first two treatment cycles. This study aims to develop a gene signature related to neutrophil extracellular traps (NETs) to enhance understanding of AML mechanisms and identify potential prognostic biomarkers. Methods: A consistent cluster analysis was conducted on 151 AML patients from the TCGA dataset. A differential analysis was performed to identify the differentially expressed genes (DEGs) specific to different subtypes and the training cohort (normal vs tumour). The NETs-related differentially expressed genes (NR-DEGs) were obtained through the overlapping of the two sets of differentially expressed genes. Univariate Cox and Least absolute shrinkage and selection operator (LASSO) regression analysis were employed to construct a NETs-related AML prognostic signature. Furthermore, an immune feature estimation and functional enrichment analysis was conducted between the two risk subgroups. Results: Two distinct AML subtypes were identified, exhibiting markedly disparate survival outcomes. A total of 1,700 and 1,941 DEGs were identified in the different subtypes and training cohort (normal vs. tumour), respectively. Thirteen NR-DEGs were identified. Subsequently, a NETs-related prognostic signature was constructed based on the 3 prognostic genes ( Conclusion: The prognostic signature comprised of

Indexed as

Biomarkers, TumorExtracellular TrapsLeukemia, Myeloid, AcuteNeutrophilsAdultAgedChemokine CCL3Computational BiologyFemaleGene Expression ProfilingGene Expression Regulation, LeukemicHumansMaleMiddle AgedPrognosisTranscriptomeBiomarkers, TumorChemokine CCL3acute myeloid leukemianeutrophil extracellular trapprognostic signaturerisk subgroupstumor microenvironment

Identifiers

PMID41208992
PMCPMC12592046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.