ArticleResearch and practice in thrombosis and haemostasis2025
Phenotyping of human platelets in response to platelet agonists and inhibitors using multiparameter flow cytometry and unbiased high-dimensional analysis.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Platelet membrane-coated nanoparticles: Bioengineering principles, quality control, and translational opportunities.APL bioengineering · 2026Review
- Markers for platelet function testing by flow cytometry: where are we now? A clinical perspective.Research and practice in thrombosis and haemostasis · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite increasing evidence of functionally distinct platelet subpopulations, the role of receptor remodeling in this process is unclear. Objectives: To develop a high-dimensional multiparameter flow cytometry panel for platelet phenotyping and subpopulation analysis. Methods: Using conventional flow cytometry, we assessed the expression of 9 platelet surface receptors in whole blood (WB) samples from healthy adults in response to different platelet activators and inhibitors. Platelet subpopulations were identified by Full Annotation Using Shape-constrained Trees (FAUST). Results: The 9-parameter assay simultaneously measured the activation of α Conclusion: Platelet subpopulations are dynamic and undergo remodeling in response to different agonists and inhibitors. This high-dimensional single-cell flow cytometry assay is a practicable approach to evaluate the effects of agonists and inhibitors on platelet receptor expression and platelet subpopulations.
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