ArticleResearch and practice in thrombosis and haemostasis2025
Neuraxial analgesia in pregnant individuals with bleeding disorders: a retrospective descriptive study of obstetric anesthesia practices and outcomes.
Article in Research and practice in thrombosis and haemostasis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Safety of von Willebrand factor substitution for neuraxial anesthesia in women with persistent von Willebrand deficiency at delivery.Research and practice in thrombosis and haemostasis · 2026Observational
- Factor XIII deficiency: an updated approach to diagnosis and management.Frontiers in medicine · 2026Review
- Factor XIII Deficiency: A Review of Biology, Testing, and Treatment.Clinical hematology international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neuraxial analgesia is an effective and advantageous technique for managing labor pain. Yet, clinicians often hesitate to offer neuraxial analgesia to parturients with inherited bleeding disorders because of fear of epidural or spinal hematoma and the absence of high-quality evidence to guide decision-making in practice. Objectives: To describe obstetric analgesia practices and outcomes in pregnant individuals with bleeding disorders managed at a tertiary care center. Methods: We performed a retrospective descriptive study of all deliveries (January 2010-July 2021) managed by the Ottawa Regional Bleeding Disorders Program. Patient, laboratory, peripartum anesthetic data, and antenatal anesthesia and hematology recommendations were collected from electronic health records and summarized descriptively. Results: Eighty-two deliveries occurred in 56 pregnant individuals (median age, 31 years). The most common disorders were type 1 von Willebrand disease (34.1%) and hemophilia A (29.3%). Neuraxial analgesia was used in 59 of 82 deliveries (72.0%). Third-trimester hemostatic profiles met predefined "adequate" thresholds in 54 of 79 evaluable deliveries (68.4%). Of the 25 deliveries below target, 13 still received neuraxial analgesia, and 10 of those received factor replacement beforehand. Antenatal recommendations from anesthesiology and hematology were documented in 47 cases, with agreement in 45 (95.7%). No epidural or spinal hematomas occurred. Minor morbidity included 1 postdural puncture headache (1.7%) and 2 cases of localized back pain (3.4%). Conclusion: With multidisciplinary planning and evidence-aligned laboratory targets, neuraxial analgesia was offered safely to most pregnant individuals with bleeding disorders within our cohort. Larger multicenter studies and registry initiatives are warranted to refine factor-specific thresholds and standardize care pathways for this patient population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.