Evidence map›Paper›PMID 41208884›Full record

ArticleInternational journal of biological sciences2025

Synergistic Effects of Radiotherapy and PD‑1 Blockade in a Human‑Mimetic BRCAness Model of Triple-Negative Breast Cancer.

Eun Ju Cho, Min Kyung Ki, Hye Jung Baek, Dong Hoon Shin, Eun Jung Park, Tae Hyun Kim, Chu-Xia Deng, Beom K Choi, Sang Soo Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eun Ju ChoResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Min Kyung KiResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Hye Jung BaekResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Dong Hoon ShinResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Eun Jung ParkResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Tae Hyun KimResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Chu-Xia DengCancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
Beom K ChoiResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.
Sang Soo KimResearch Institute, National Cancer Center Research Institute, Goyang, 10408, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BRCA1‑deficient triple‑negative breast cancer (TNBC) presents significant treatment challenges owing to the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) targets, exhibits marked molecular heterogeneity that precludes the application of effective targeted therapies, and harbors a highly immunosuppressive tumor microenvironment. Here, we used the

Indexed as

BRCA1 ProteinProgrammed Cell Death 1 ReceptorTriple Negative Breast NeoplasmsAnimalsApoptosisDisease Models, AnimalFemaleHumansMiceBRCA1 ProteinProgrammed Cell Death 1 ReceptorBRCA1breast cancerimmune checkpointirradiationPD-1

Identifiers

PMID41208884
PMCPMC12594595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.