ArticleAdvanced healthcare materials2026
A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- A mechanically actuated lung microvascular model reveals that breathing-like deformation enhances tumor cell extravasation.bioRxiv : the preprint server for biology · 2026Article
- A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment.Advanced healthcare materials · 2026Article
- Differential effects of aerobic, resistance, and combined exercise on skeletal muscle function in high-fat diet-induced obese mice: integration of gut microbiota and metabolomics.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Systemic inflammation associated with obesity impairs skeletal muscle function through paracrine signaling from intermuscular adipose tissue-adipose depots situated between adjacent skeletal muscle groups-as well as from visceral adipose tissue, which consist of infiltrating macrophages surrounding inflamed adipocytes. These signals disrupt metabolic homeostasis and reduce muscle contractility, yet existing models are limited in their ability to recapitulate the crosstalk between skeletal muscle and inflamed adipose tissue in a physiologically relevant context. To address this, a human cell-based microphysiological system is developed that combines engineered muscle tissue (EMT) with an inflamed adipose-macrophage co-culture (IAMC) to model obesity-associated muscle dysfunction. EMTs, derived from human myoblasts on micropillar devices, self-assembled into 3D contractile myobundles. IAMC are generated by co-culturing inflamed adipocytes with pro-inflammatory M1-polarized macrophages, thereby recapitulating the obese inflammatory microenvironment. EMT-IAMC co-culture significantly reduced muscle contractility. Furthermore, cytokine profiling revealed elevated levels of pro-inflammatory mediators, and transcriptomic analysis showed metabolic reprogramming in EMTs, including upregulation of genes linked to fatty acid transport and insulin resistance. Collectively, these findings underscore the detrimental effects of inflamed adipose tissue on skeletal muscle function and suggest the potential utility of an interfaced platform for studying adipose-muscle interactions and screening therapies for obesity-related muscle dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.