Evidence map›Paper›PMID 41208700›Full record

ArticleImmunity, inflammation and disease2025

The Imbalanced Patterns and Clinical Significance of Cytokines in Acute Myeloid Leukemia Microenvironment.

Rong Wang, Keying Jing, Huijuan Zhao, Guoguang Zheng, Jun Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rong WangDepartment of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-9303-4714
Keying JingHenan University People's Hospital, Department of Clinical Laboratory, Henan Provincial People's Hospital, Henan University, Zhengzhou, China.
Huijuan ZhaoBasic Medical College, Henan University of Science and Technology, Luoyang, China.
Guoguang ZhengState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Jun CaiDepartment of Clinical Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, China.ORCID https://orcid.org/0009-0001-5249-5805

Funding

This study was funded by grant from the National Natural Science Foundation of China (NSFC) (82002210) and the Foundation of Henan' Educational Committee (232102311127).
6 · The paper itself

Abstract

introductionAcute myeloid leukemia (AML) is known for its unfavorable prognosis, prompting research efforts of cytokines in the microenvironment to explore new therapeutic targets. Here, we investigated the complex cytokine networks in both AML mice and AML patients to reveal the role of cytokines in AML pathogenesis.

methodsAs a basis for further studies on human, the patterns of cytokines were detected in AML mice by cytokine array panel, and the patterns of cytokines were detected in AML patients by Luminex liquid suspension chip and ELISA. Leukocyte subpopulations in human were analyzed by flow cytometry. Additionally, the associations of cytokine levels with the outcome of AML patients were analyzed by Cox regression analysis, the overall survival curve was assessed by Kaplan-Meier method. Furthermore, Pearson correlation analysis was used for the correlation analysis of continuous variables.

resultsThe imbalanced patterns of cytokines were observed in AML mice. Furthermore, higher levels of CCL3, CCL4 and CXCL10, independent of sex, age, FAB phenotype, patient status and risk molecular, were associated with the poor outcome of AML patients recruited in our study by Cox regression analysis. Additionally, the survival analysis demonstrated that the CCL3

conclusionThe imbalanced patterns of cytokines were observed in both AML mice and AML patients. Interestingly, 3 cytokines (CCL3, CCL4 and CXCL10) were related to the outcome of AML patients, suggesting they are valuable for AML prognosis. Furthermore, the change of leukocyte subpopulations, either as causes or as consequences, may partially account for the change of cytokines in AML condition.

Indexed as

CytokinesLeukemia, Myeloid, AcuteTumor MicroenvironmentAdultAgedAnimalsChemokine CCL3Chemokine CCL4Chemokine CXCL10Clinical RelevanceFemaleHumansMaleMiceMiddle AgedPrognosisChemokine CCL3Chemokine CCL4Chemokine CXCL10Cytokinesacute myeloid leukemiacytokineimbalanced profileleukocyte subpopulationmicroenvironment

Identifiers

PMID41208700
PMCPMC12598404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.