ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Efficient, Functional Group-Tolerant, and Catalyst-Free Nitrile Formation from Aldehydes.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The development of efficient methods for nitrile syntheses is a challenge due to the current reliance on toxic cyanide sources, metal catalysts and their associated waste products, and harsh conditions that limit functional group compatibility. Here, we show a metal- and complex reagent-free strategy for the conversion of aldehydes to nitriles through carbamoylaldoxime intermediates. Therefore, we synthesize aldoximes from several aldehydes using hydroxylamine, which in turn are reacted with dimethylcarbamoyl chloride (DMCC) to afford N,N-dimethylcarbamoyloximes. Subsequent heating cleanly produces the desired nitriles as well as volatile CO
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