ArticleJournal of cachexia, sarcopenia and muscle2025
Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Lean Body Mass Associates With a Hypertensive Cardiovascular Phenotype in Men but Not in Women.Journal of cachexia, sarcopenia and muscle · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundLean body mass (LBM) is independently associated with the function and structure of the cardiovascular (CV) system in women and genetically predisposed men with low LBM. Yet, the relationship between LBM and the CV system remains uncertain in the general population comprising a wide spectrum of LBM.
methodsA total of 325 healthy women (n = 162) and men (n = 163) throughout the adult lifespan (18-78 years) matched by age (age = 43 ± 18 vs. 44 ± 18 years) and physical activity were included. Body composition, including LBM, fat and bone mass, was assessed in total and per body region (legs, arms and trunk) by dual-energy x-ray absorptiometry. Left ventricular (LV) mass and structure as well as peripheral and central haemodynamics were determined via echocardiography and continuous blood pressure measurements.
resultsWomen presented with lower total LBM (p < 0.001) and higher body fat (p < 0.001) than men. Total LBM did not associate with systolic blood pressure (SBP) in women (p = 256) but did positively associate with SBP in men (r = 0.31, p < 0.001). Total LBM did not associate with LV concentric hypertrophy (LVRWTd) in women (p = 448) but did positively associate with LVRWTd in men (r = 0.24, p = 0.003). Similar sex-specific associations were observed for regional LBM, except for arm LBM, which associated with all study variables in women. Adjustment by body fat or body fat percentage did not modify the results.
conclusionsTotal LBM independently associates with a hypertensive CV phenotype in men, whereas regional LBM, specifically in the arms, is linked with the same detrimental phenotype in women.
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