ArticleBiomacromolecules2025
Bioorthogonal Suzuki-Miyaura Cross-linking: Transforming Responsive Hydrogels into Permanent Polymer Networks.
Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this study, we present a novel approach to convert reversible polymer networks into stable, nonresponsive networks using bio-orthogonal Suzuki-Miyaura coupling (SMC). By leveraging boronic acids, which form reversible boronate esters with cis-diols for shear-thinning injectable gels and serve as SMC substrates to create stable C-C bonds, we achieve switching from responsive to nonresponsive behavior. We demonstrate the concept with a responsive precursor based on sodium alginate modified with phenyl boronic acid, cross-linked with three model iodide-functionalized (macro-)molecules that exhibit irreversible gelation under bio-orthogonal conditions. The resulting networks exhibit robust mechanical stability, minimal pH and temperature responsiveness, high degradation resistance and excellent hemocompatibility. The proposed approach underlines the potency of SMC as a robust synthetic strategy toward the synthesis and transformation of polymer networks for advanced biomedical applications.
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