ReviewAndrology2026
Oxidative Stress and its Implications for Male Reproductive Dysfunction: Mechanistic Insights, Clinical Impacts, and Advances in Therapeutic Interventions.
Review in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Nano-Rosmarinic Acid Protects Against Chlorfenapyr-Induced Testicular Toxicity Through Modulation of NRF2/HO-1 and NF-κB/NLRP3 Signaling Pathways.Journal of biochemical and molecular toxicology · 2026Article
- Metabolic Syndrome and Male Infertility: The Role of Obesity and Chronic Inflammation.Biomedicines · 2026Review
- Review
- Dietary patterns and sperm DNA fragmentation in idiopathic infertile men: A case-control study.Scientific reports · 2026Article
- Swadamshtradi rasayana attenuates radiofrequency radiation-induced oxidative stress and improves sperm parameters in Swiss albino mice.Frontiers in reproductive health · 2026Article
- Environmental determinants of male infertility: emerging threats and technological interventions.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress (OS) significantly contributes to male reproductive dysfunction, a factor implicated in a substantial fraction of infertility cases. This comprehensive review elucidates the intricate interplay between oxidative stress and male reproductive health, emphasizing the molecular and cellular mechanisms through which reactive oxygen species (ROS) impair sperm function. Key areas of focus include lipid peroxidation of sperm membranes, DNA damage, and apoptotic cell death, which collectively undermine sperm viability and fertility potential. The discussion extends to the impact of lifestyle and environmental factors on oxidative balance, highlighting how these elements intensify oxidative stress and subsequently exacerbate reproductive outcomes. Advances in therapeutic approaches are critically assessed, particularly the development and application of antioxidants in ameliorating oxidative damage and restoring reproductive functions. This review also explores innovative diagnostic techniques for detecting ROS and assessing oxidative damage within clinical settings, offering insights into future directions for research and clinical practice in managing male infertility related to oxidative stress.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.