Evidence map›Paper›PMID 41208153›Full record

ArticleJournal of medicinal chemistry2025

Crizotinib- or Ceritinib-Conjugated Platinum(IV) Prodrugs As Potent Multiaction Agents Inducing Antiproliferative Effects in 2D and 3D Cancer Cell Models.

Sofia Sharkawy, Sourav Acharya, Hana Kostrhunová, Moumita Maji, Lenka Marková, Vojtěch Novohradský, Dan Gibson, Viktor Brabec

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sofia SharkawyFaculty of Science, Department of Biochemistry, Masaryk University, CZ-62500 Brno, Czech Republic.ORCID 0009-0009-3032-953X
Sourav AcharyaInstitute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem-9112102, Israel.ORCID 0000-0001-5511-1312
Hana KostrhunováCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.ORCID 0000-0003-2706-6491
Moumita MajiInstitute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem-9112102, Israel.ORCID 0000-0003-3440-0881
Lenka MarkováCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.ORCID 0000-0003-1640-6163
Vojtěch NovohradskýCzech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61200 Brno, Czech Republic.ORCID 0000-0003-4381-8403
Dan GibsonInstitute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem-9112102, Israel.ORCID 0000-0002-1631-4018
Viktor BrabecDepartment of Biophysics, Faculty of Science, Palacky University, Slechtitelu 27, 783 71 Olomouc, Czech Republic.ORCID 0000-0002-8233-1393

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel Pt(IV) complexes conjugated with the kinase inhibitors crizotinib or ceritinib were synthesized and assessed for anticancer activity. Cisplatin-derived derivatives bearing phenylbutyrate and either crizotinib (complex

Indexed as

Antineoplastic AgentsCrizotinibOrganoplatinum CompoundsProdrugsPyrimidinesSulfonesApoptosisCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorHumansPlatinumProtein Kinase InhibitorsStructure-Activity RelationshipAntineoplastic AgentsceritinibCrizotinibOrganoplatinum CompoundsPlatinumProdrugsProtein Kinase InhibitorsPyrimidinesSulfones

Identifiers

PMID41208153
PMCPMC12670396

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.