Evidence map›Paper›PMID 41207969›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Intraoperative neuromonitorig alert risks in patients submitted to anterior cervical decompression and fusion for cervical spondylotic myelopathy: a single institution cohort-study.

Marco Battistelli, Alessandro Rapisarda, Massimo Benenati, Fabio Sbaraglia, Massimiliano Visocchi, Nicola Montano, Martina Taglialatela, Federico Costa, Ignazio Friscia, Michele Di Domenico and 6 more

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Marco BattistelliDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.
Alessandro RapisardaDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy. alessandro.rapisarda@guest.policlinicogemelli.it.
Massimo BenenatiDipartimento di Diagnostica per Immagini, Radioterapia, Oncologia ed Ematologia, Agostino Gemelli University Polyclinic, Rome, Italy.
Fabio SbaragliaDepartment of Anesthesiology and Intensive Care Medicine, Agostino Gemelli University Polyclinic, Rome, Italy.
Massimiliano VisocchiDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.
Nicola MontanoDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.
Martina TaglialatelaDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.
Federico CostaCatholic University of the Sacred Heart, Rome, Italy.
Ignazio FrisciaCatholic University of the Sacred Heart, Rome, Italy.
Michele Di DomenicoAgostino Gemelli University Polyclinic, Rome, Italy.
Mario MuselliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Giuseppe Maria Della PepaCatholic University of the Sacred Heart, Rome, Italy.
Marco RossiCatholic University of the Sacred Heart, Rome, Italy.
Simona GaudinoCatholic University of the Sacred Heart, Rome, Italy.
Francesco DogliettoDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.
Filippo Maria PolliDepartment of Neurosurgery, Agostino Gemelli University Polyclinic, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify positional and intraoperative significant multimodal intraoperative neurophysiological monitoring (mIONM) alert risk factors during anterior cervical surgery in patients with cervical spine myelomalacia.

methodsWe analyzed prospectively collected data from the PANDA registry between January 2021 and February 2025. Included were patients undergoing anterior cervical decompression and fusion with MRI-confirmed myelomalacia. A significant alert was defined as a ≥ 50% reduction in MEP and/ SSEP amplitude, a ≥ 10% increase in MEP latency, or a spEMG signal. Patients were categorized into three groups: significant warnings at positioning (Group A), during surgical decompression (Group B), and no significant warnings (Group C). Nineteen anamnestic, clinical, radiological, and surgical factors were evaluated. A standardized anesthesia protocol and alert-response strategy were applied.

resultsSeventy-six patients (132 operated levels) were included. Four patients belonged to Group A and 12 to Group B. Group A exhibited only MEP alerts and showed higher prevalence of peripheral vascular disorders, C3-C4 surgeries, and poorer motor scores in the most affected muscle group; the latter independently predicted alerts with 100% sensitivity at an mMRC threshold of 4. Group B was characterized by only MEP and EMG alerts, significantly longer symptom duration, and myelomalacia spanning two to three levels. Both factors independently predicted intraoperative alerts and were protective when symptom duration was less than 37 months and myelomalacia involved less than two levels. No SSEP alerts occurred.

conclusionThese findings support the use of mIONM during positioning and surgical decompression in anterior cervical procedures for patients with cervical myelomalacia, especially in those with segmental motor deficits, prolonged symptoms, and multilevel myelomalacia.

Indexed as

Cervical VertebraeDecompression, SurgicalIntraoperative Neurophysiological MonitoringSpinal Cord DiseasesSpinal FusionSpondylosisAgedCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsAnterior cervical spine surgeryCervical spondylotic myelopathyCohort-studyNeck extension alertNeurophysiologic monitoringSurgical decompression alert

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.