Evidence map›Paper›PMID 41207872›Full record

ArticleThe European journal of neuroscience2025

Ex Vivo Modulation of the BNST by Parabrachial CGRP Projections Is Decreased After a History of Stress-Induced Anxiety.

L S Kayat, N Petersen, C E Van Doorn, B P Nabit, J B Tyree, S W Centanni, A A Jaramillo

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

L S KayatSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
N PetersenSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
C E Van DoornDepartment of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
B P NabitSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
J B TyreeDepartment of Pharmaceutical Sciences, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA.
S W CentanniSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
A A JaramilloSchool of Medicine, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-6267-4196

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Understanding the role of anti-apolipoprotein A-I antibodies in atherosclerotic cardiovascular diseaseP20GM130456 · NIGMS · UNIVERSITY OF KENTUCKY · PI Yosra A. Helmy · 2020 to 2026
$18.7M
Research Training in Drug Abuse BehaviorT32DA035200 · NIDA · UNIVERSITY OF KENTUCKY · PI CRAIG R RUSH, William Walton Stoops · 2013 to 2026
$4.4M
Norepinephrine-dopamine interactions underlying arousalR01NS102306 · NINDS · EMORY UNIVERSITY · PI MITRANO, DARLENE A, WEINSHENKER, DAVID · 2017 to 2021
$1.8M
Insular cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affectR00AA027774 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CENTANNI, SAMUEL · 2022 to 2024
$832k
Neuropeptide-dependent parabrachial control of the BNST during alcohol abstinence-induced negative affectR00AA029467 · NIAAA · UNIVERSITY OF KENTUCKY · PI JARAMILLO, ANEL ARIANA · 2023 to 2025
$738k
Neuropeptide-dependent parabrachial control of the BNST during alcohol abstinence-induced negative affectK99AA029467 · NIAAA · VANDERBILT UNIVERSITY · PI JARAMILLO, ANEL ARIANA · 2021 to 2022
$302k
Insular Cortex-BNST neural circuit regulation of chronic alcohol abstinence-induced negative affectK99AA027774 · NIAAA · VANDERBILT UNIVERSITY · PI CENTANNI, SAMUEL · 2020 to 2021
$300k
Neuron-astrocyte interactions mediating ethanol and noradrenergic modulation of wake-promoting vPAG dopamine neuronsF30AA029599 · NIAAA · VANDERBILT UNIVERSITY · PI PETERSEN, NICHOLAS · 2022 to 2024
$115k
Extended amygdala mGlu8 receptor signaling in stress-reward interactionsF31DA054774 · NIDA · VANDERBILT UNIVERSITY · PI NABIT, BRETTON · 2021 to 2023
$95k
NIAAA NIH HHS AA027774NIAAA NIH HHS AA029467NIAAA NIH HHS AA029599NIAAA NIH HHS F30 AA029599NIAAA NIH HHS K99 AA027774NIAAA NIH HHS K99 AA029467NIAAA NIH HHS R00 AA027774NIAAA NIH HHS R00 AA029467NIDA NIH HHS DA035200NIDA NIH HHS DA054774NIDA NIH HHS F31 DA054774NIDA NIH HHS T32 DA035200NIGMS NIH HHS GM007347NIGMS NIH HHS GM130456NIGMS NIH HHS P20 GM130456NIGMS NIH HHS T32 GM007347NINDS NIH HHS NS102306-04S1NINDS NIH HHS R01 NS102306
6 · The paper itself

Abstract

Activity in the parabrachial calcitonin gene-related peptide to bed nucleus of the stria terminalis (PBN[CGRP] → BNST) circuit associates with anxiety-like behavior. To test whether previous stress-induced anxiety is associated with neuronal adaptations in the PBN (CGRP) → BNST circuit, C57 mice were exposed to 4 days of daily forced swim stress (FSS). The novelty-suppressed feeding test (NSFT) demonstrated repeated FSS increased anxiety-like behavior. To assess if repeated FSS potentiates anxiety-like behavior in mice with dysregulated affect, mice received chronic intermittent ethanol vapor followed by FSS in abstinence. Anxiety-like behavior measured by NSFT was potentiated by repeated FSS in alcohol-abstinence. To measure neuroadaptations associated with a history of stress, Calca

Indexed as

AnxietyCalcitonin Gene-Related PeptideParabrachial NucleusSeptal NucleiStress, PsychologicalAnimalsEthanolMaleMiceMice, Inbred C57BLCalcitonin Gene-Related PeptideEthanolabstinencealcoholanxietybed nucleus of the stria terminalisparabrachial nucleusstress

Identifiers

PMID41207872
PMCPMC12597655

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.