Evidence map›Paper›PMID 41207868›Full record

ArticleMagnetic resonance in medicine2026

ASL 4D MRA Intracranial Vessel Segmentation With Deep Learning U-Nets.

Sang Hun Chung, Zihan Wang, Tianrui Zhao, Zhitao Li, Chase S Krumpelman, Sarah J Moum, Sameer A Ansari, Lirong Yan

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sang Hun ChungDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-0605-9420
Zihan WangDepartment of Electrical and Computer Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois, USA.
Tianrui ZhaoDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0007-0889-5629
Zhitao LiDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3462-6549
Chase S KrumpelmanDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sarah J MoumDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sameer A AnsariDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lirong YanDepartment of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-5173-7059

Funding

Quantitative cerebral blood vessel imaging biomarkers for AD and VCIDRF1AG072490 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG, YAN, LIRONG · 2021 to 2021
$2.4M
Imaging of cerebral microvascular pulsatility in cerebral small vessel diseaseRF1NS139370 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YAN, LIRONG · 2024 to 2024
$2.3M
Quantitative ASL MR angiography and perfusion imaging for cerebral revascularizationR01NS118019 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YAN, LIRONG · 2020 to 2024
$2.0M
BrightFocus Foundation A20201411SNIA NIH HHS RF1 AG072490NIA NIH HHS RF1AG072490NINDS NIH HHS R01 NS118019NINDS NIH HHS R01NS118019NINDS NIH HHS RF1 NS139370NINDS NIH HHS RF1NS139370
6 · The paper itself

Abstract

purposeTo propose a spatio-temporal U-Net based network (4DST) that exploits both spatial and dynamic information while avoiding memory-intensive 4D convolutional layers for ASL-based non-contrast enhanced 4-dimensional MR angiography (4D MRA) vessel segmentation.

methodsPulsed ASL-based 4D MRA data were collected on 35 healthy volunteers and 5 arteriovenous malformation patients. Spatial only (2D, 3D) and spatio-temporal U-Net variations (including the proposed 4DST) were tested. Two recently developed methods, including feature-based isolation forest and BRAVE-Net, were used for comparison. Dice-Sørensen coefficient (DSC), center-line Dice (clDice), Hausdorff distance (HD), precision, accuracy, specificity, and sensitivity were calculated. Sensitivity was analyzed relative to SNR and arterial transit time (ATT) to explore detectability. From graph analysis, total vessel length, number of branches, and number of endpoints were reported.

results4DST achieved the best DSC, clDice, and HD (0.876 ± 0.03, 0.865 ± 0.02, 6.241 ± 0.95, respectively). 4DST outperformed all other models across the SNR range of 1 to 10 and arterial transit time range of 500 to 800 ms in sensitivity. Last, the 4DST segmentations yielded total lengths and the number of branch splits that more closely matched the ground truths compared to the other models.

conclusionThe proposed 4DST network architecture offers an overall improvement in 4D MRA vessel segmentation performance over the compared methods and provides the framework for an end-to-end trainable model for spatio-temporal datasets. Additionally, 4DST requires minimal pre/post-processing steps, rendering it an attractive solution for pulsed ASL-based 4D MRA vessel segmentation.

Indexed as

BrainDeep LearningImage Processing, Computer-AssistedIntracranial Arteriovenous MalformationsMagnetic Resonance AngiographyAdultAlgorithmsFemaleHealthy VolunteersHumansImaging, Three-DimensionalMaleMiddle AgedSensitivity and SpecificitySignal-To-Noise RatioYoung Adult4D MRAarteriovenous malformationASLdeep learningU‐netvessel segmentation

Identifiers

PMID41207868
PMCPMC12850589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.