Evidence map›Paper›PMID 41207696›Full record

ArticleVirulence2025

Severe fever with thrombocytopenia syndrome virus infection induces thymic atrophy in IFNAR

Longda Ma, Hui Zhang, Manli Wang, Zhihong Hu, Yiwu Zhou, Jia Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virulence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Longda MaDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Hui ZhangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Manli WangState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Zhihong HuState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Yiwu ZhouDepartment of Forensic Medicine, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China.
Jia LiuState Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0003-0591-9895

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) causes severe disease in humans, yet the pathogenesis remains poorly understood. A hallmark of fatal SFTS cases is the marked depletion of T cells. Previous studies on T cell depletion have predominantly focused on alterations in blood and peripheral lymphoid organs, while the thymus, a critical site for T cell development, has remained largely overlooked. In this study, we employed a lethal murine infection model to investigate the impact of SFTSV on thymic function. Our results revealed that SFTSV infected the thymus and induced severe cortical atrophy in type I interferon receptor-deficient (IFNAR

Indexed as

PhlebovirusReceptor, Interferon alpha-betaSevere Fever with Thrombocytopenia SyndromeThymus GlandAnimalsApoptosisAtrophyDendritic CellsDisease Models, AnimalInterferon-gammaMacrophagesMiceMice, Inbred C57BLMice, KnockoutThymocytesIfnar1 protein, mouseInterferon-gammaReceptor, Interferon alpha-betadouble-positive (DP) cells depletionelevated IFN-γincreased apoptosisSevere fever with thrombocytopenia syndrome virusthymic atrophy

Identifiers

PMID41207696
PMCPMC12629347

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.