Evidence map›Paper›PMID 41207218›Full record

ArticleEnvironment international2025

Preconception, gestation, and childhood exposure to air pollution and risk of polycystic ovary syndrome (PCOS) in a US girls cohort study.

Elizabeth Peebles, Makiko Mitsunami, Boya Zhang, Jie Chen, Brent A Coull, Tamarra James-Todd, Jorge E Chavarro, Jaime E Hart, Francine Laden, Shruthi Mahalingaiah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Elizabeth PeeblesDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Makiko MitsunamiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Integrated Center for Women's Health, National Center for Child Health and Development, 2 Chome-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan. Electronic address: mmitsunami@hsph.harvard.edu.
Boya ZhangDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Jie ChenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Brent A CoullDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Building 2 655 Huntington Avenue, Boston, MA 02115, USA.
Tamarra James-ToddDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Jorge E ChavarroChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Building 1 665 Huntington Avenue, Boston, MA 02115, USA.
Jaime E HartDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
Francine LadenDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.
Shruthi MahalingaiahDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit Street Yawkey 10, Boston, MA 02114, USA.

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Integrating lifecourse approaches, biologic and digital phenotypes in support of heart and lung disease epidemiologic researchU01HL145386 · NHLBI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO, MANSON, JOANN ELISABETH · 2019 to 2025
$17.8M
Climate factors, racial/ethnic disparities, and menstrual cycle healthR01ES035106 · NIEHS · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Shruthi Mahalingaiah · 2023 to 2026
$2.2M
NHLBI NIH HHS U01 HL145386NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES035106
6 · The paper itself

Abstract

backgroundExposure to ambient air pollution (AP) during sensitive developmental periods could dysregulate the reproductive system, resulting in later in life menstrual disorders, including polycystic ovary syndrome (PCOS). Minimal research exists examining the relationship between AP exposure and PCOS.

objectivesTo determine if residential ambient particulate matter (PM) and nitrogen dioxide (NO

methodsWe used data from 3,321 female participants with gestational data available born between 1989 and 1994 in the Growing Up Today Study 2 (GUTS2), an ongoing United States (US) cohort initiated in 2004. Exposure to ambient PM (≤2.5, 2.5-10, and ≤ 10 μm) and NO

resultsIn total, 7.1 % of participants self-reported a PCOS diagnosis. Exposure to PM DISCUSSION: Higher exposure to PM

Indexed as

Air PollutantsAir PollutionEnvironmental ExposurePolycystic Ovary SyndromePrenatal Exposure Delayed EffectsAdolescentAdultChildCohort StudiesFemaleHumansMaternal ExposureNitrogen DioxideParticulate MatterPregnancyUnited StatesAir PollutantsNitrogen DioxideParticulate MatterAir pollutionEnvironmental exposureNitrogen dioxideParticulate matterPolycystic ovary syndromeReproductive healthTraffic-related air pollution

Identifiers

PMID41207218
PMCPMC12810124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.