ArticleBiological trace element research2026
Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4.
Article in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- The Interaction Between Iron and Selenium Affects Ferroptosis in Colorectal Cancer.International journal of molecular sciences · 2026Review
- Exploratory comparative profiling of 22 macro- and trace elements reveals disrupted elemental homeostasis in colorectal cancer tissues.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, necessitating novel therapeutic strategies. This study demonstrates that high-dose sodium selenite (Na₂SeO₃) induces ferroptosis in CRC cells by directly targeting the Nrf2/Gpx4 antioxidant pathway. Critically, molecular docking analysis confirmed strong binding interactions between Na₂SeO₃ and both the Nrf2 and Gpx4 proteins, suggesting a direct mechanistic link. Clinical samples from CRC patients revealed significantly decreased serum selenium levels, which correlated negatively with tumor markers (CEA, CA199, CA125) and positively with nutritional indicators (hemoglobin, albumin). Immunohistochemistry confirmed elevated Gpx4 and Nrf2 expression in tumor tissues. In vitro experiments using HCT116 cells showed that Na₂SeO₃ treatment inhibited proliferation, increased intracellular Fe
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Registered trials
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