ArticleChemSusChem2025
Molar-Scale Phenolic Acid Decarboxylation Using Thermostable Biocatalysts and Enzyme-Compatible Deep Eutectic Solvents.
Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents.Organic process research & development · 2026Article
- Molar-Scale Phenolic Acid Decarboxylation Using Thermostable Biocatalysts and Enzyme-Compatible Deep Eutectic Solvents.ChemSusChem · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The synthesis of biogenic hydroxy styrenes by enzymatic decarboxylation of phenolic acids (e.g., ferulic, p-coumaric, caffeic, or sinapic acids) is a promising route involving biorefineries and biocatalysis, in which the low substrate solubility in water requires the quest for nonconventional media. This work explores the tunability of deep eutectic solvents (DES) to simultaneously create enzyme-compatible and solubilizing systems, in which thermostable phenolic acid decarboxylases (PAD) may operate at 50-70 °C, decreasing the inherent DES viscosity. Four DESs displaying high solubility of ferulic acid are assessed (with additions of up to 20 vol% of phosphate buffer): Choline chloride-glycerol (ChCl-Gly, 1:2), choline chloride-ethylene glycol (ChCl-EG, 1:2), choline acetate-glycerol (ChAc-Gly, 1:2), and betaine-glycerol (Bet-Gly, 1:2). Bet-Gly DES exerts promising properties, being a halide-free solvent, an enzyme-stabilizer at 50-70 °C (1.4 higher melting temperatures for the N31 ancestor Bacillus subtilis PAD), and 14-fold higher ferulic acid solubility compared to buffer. Intensified conditions of up to 1 M ferulic acid (≈200 g L
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.