Evidence map›Paper›PMID 41206474›Full record

ArticleNucleic acids research2026

The current landscape of adaptive immune receptor genomic and repertoire data: OGRDB and VDJbase.

William D Lees, Ayelet Peres, Vered Klein, Naama Amos, Uddalok Jana, Eric Engelbrecht, Zachary Vanwinkle, Yaniv Malach, Thomas Konstantinovsky, Pazit Polak and 2 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Priming of Multiple HIV Neutralizing B Cell Precursors in Humans.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Revised Adaptive Immune Receptor Data in the Immune Epitope Database.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

William D LeesClareo Biosciences, Louisville, KY 40202, United States.ORCID 0000-0001-9834-6840
Ayelet PeresDepartment of Pathology, Yale School of Medicine, New Haven, CT 06510, United States.
Vered KleinFaculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.ORCID 0009-0002-4289-4017
Naama AmosFaculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.
Uddalok JanaDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States.ORCID 0009-0003-0134-7874
Eric EngelbrechtDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States.
Zachary VanwinkleDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States.
Yaniv MalachFaculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.
Thomas KonstantinovskyFaculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.
Pazit PolakFaculty of Engineering, Bar Ilan University, 5290002 Ramat Gan, Israel.
Corey T WatsonDepartment of Biochemistry and Molecular Genetics, University of Louisville, Louisville, KY 40202, United States.ORCID 0000-0001-7248-8787
Gur YaariDepartment of Pathology, Yale School of Medicine, New Haven, CT 06510, United States.ORCID 0000-0001-9311-9884

Funding

Population genotyping of the germline immunoglobulin repertoire in AIDS-designated rhesus macaque breeding coloniesR24AI162317 · NIAID · EMORY UNIVERSITY · PI Steven Edward Bosinger, Corey Taylor Watson · 2021 to 2026
$5.5M
i-AKC: Integrated AIRR Knowledge CommonsU24AI177622 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI LINDSAY G. COWELL · 2023 to 2026
$4.0M
ISF 2940/21Ministry of Innovation 1001576181/0004941NIAID NIH HHS R24 AI162317NIAID NIH HHS U24 AI177622NIHVATAT
6 · The paper itself

Abstract

Accurate characterization of adaptive immune receptor repertoires through high-throughput sequencing is critical for understanding immune responses, disease biomarkers, vaccine design, and antibody engineering. However, progress depends on precise knowledge of germline reference sequences, which are challenging to define due to extensive allelic variation and structural complexity in immunoglobulin and T cell receptor loci. To address these challenges, we present major updates to two complementary community resources: the Open Germline Receptor Database (https://ogrdb.airr-community.org) and VDJbase (https://www.vdjbase.org). These resources enable reproducible, evidence-based analysis of immune receptor diversity across populations and species, supporting both fundamental immunology research and precision medicine applications.

Indexed as

Adaptive ImmunityDatabases, GeneticReceptors, Antigen, T-CellReceptors, ImmunologicAnimalsGenomicsHigh-Throughput Nucleotide SequencingHumansReceptors, Antigen, T-CellReceptors, Immunologic

Identifiers

PMID41206474
PMCPMC12807691

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.