ArticleNucleic acids research2026
BRENDA in 2026: a Global Core Biodata Resource for functional enzyme and metabolic data within the DSMZ Digital Diversity.
Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- The DSMZ Digital Diversity Annotation Hub: a pipeline for database expansion via text mining and human curation.Journal of integrative bioinformatics · 2026Article
- Managing complexity in research data management for heterogeneous biotechnological data: a perspective on interacting as data steward.Bioprocess and biosystems engineering · 2026Review
- Caspase-1 inhibition: mechanistic insights and comprehensive review of reported inhibitors to date.Inflammopharmacology · 2026Review
- Caution: fundamental data quality issues underlying intelligent prediction of enzyme optimal pH.Briefings in bioinformatics · 2026Article
- Fast structural search for classification of gut bacterial mucin O-glycan degrading enzymes.PLoS computational biology · 2026Article
- The Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerate.Molecular cell · 2026Article
- Metabolic engineering ofbioRxiv : the preprint server for biology · 2026Article
- AUKAT: Conditional VAE-Driven Augmentation and Neural Modeling of Enzyme Turnover Numbers.Biomolecules · 2026Article
- TridentSynth: a webtool for the retrosynthesis of molecules using chimeric type I polyketide synthases and chemoenzymatic pathways.Nucleic acids research · 2026Article
- A historical journey of metabolite-protein interaction discovery: from data harmonization to AI-driven prediction.Briefings in bioinformatics · 2026Review
- Optimizing protein tokenization: reduced amino acid alphabets for efficient and accurate protein language models.Bioinformatics (Oxford, England) · 2026Article
- Nutrient control enables metabolic reconstruction ofbioRxiv : the preprint server for biology · 2026Article
- A bifidobacterial enzyme orchestrates ecology and function of infant gut bacterial community.bioRxiv : the preprint server for biology · 2026Article
- TogoMCP: natural language querying of life-science knowledge graphs via schema-guided LLMs and the Model Context Protocol.Database : the journal of biological databases and curation · 2026Article
- The 2026 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
BRENDA (https://www.brenda-enzymes.org/), the most comprehensive enzyme and ligand database for over nearly four decades, has seen major developments since 2021, further solidifying its role as an ELIXIR Core Data Resource and Global Core Biodata Resource in the life sciences. As part of the DSMZ Digital Diversity consortium (https://hub.dsmz.de) since 2023, BRENDA has introduced a prototype knowledge graph accessible via a public SPARQL endpoint, enabling semantic search, data integration, and improved reusability in line with FAIR principles. The database now hosts ∼5.8 million data points on 112 288 enzymes from 15 335 organisms and 173 164 references, alongside 278 840 ligands. Recent updates include the manual annotation of ∼16 000 references, the addition of 615 EC numbers-480 with newly curated data-and revisions to 4422 EC classes. The curated pathway collection has expanded to 195 metabolic maps, now supported by interactive pathway summary pages that organize key information into structured, user-friendly views. BRENDA now also incorporates DSMZCellDive data, visually linking enzyme classes to high-expressing human cell lines. A new gene-centric search interface allows streamlined access to enzyme-specific data using gene symbols or identifiers. These enhancements advance BRENDA's interoperability and analytical capabilities, reinforcing its integration with major bioinformatics resources such as SILVA, BacDive, and LPSN.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.