Evidence map›Paper›PMID 41206417›Full record

ArticleMolecular neurobiology2025

The Combination of Sodium Tanshinone IIA Sulfonate and Mesenchymal Stem Cell-derived Exosomes Against Spinal Cord Injury via VEGF Pathway.

Dan Luo, Lin Ma, Zhijian Pan, Ling Chen, Zhifeng Hu, Chaolun Liang, Zenglu Wang, Zhifeng Xiao, Dingkun Lin, Jinfeng Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dan Luo *Spinal Minimally Invasive Department, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, Guangdong, China.
Lin Ma *Laboratory of Osteology and Traumatology of Traditional Chinese Medicine, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510120, Guangdong, China.
Zhijian PanDepartment of Orthopedics, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510000, Guangdong, China.
Ling ChenDepartment of Orthopedics, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, 510000, Guangdong, China.
Zhifeng HuZhongshan Hospital of Traditional Chinese Medicine, Affiliated to Guangzhou University of Chinese Medicine, Zhongshan, 528400, Guangdong, China.
Chaolun LiangDepartment of Orthopedics (Joint Surgery), Guangdong Provincal Hospital of Chinese Medicine, Zhuhai, 519015, Guangdong, China.
Zenglu WangICU Critical Care Medicine Department, Guangdong Second Provincial Traditional Chinese Medicine Hospital, Guangzhou, 510030, Guangdong, China.
Zhifeng XiaoState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness, Syndrome of Chinese Medicine, Department of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, 510120, Guangdong, China.
Dingkun LinState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness, Syndrome of Chinese Medicine, Department of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, 510120, Guangdong, China.
Jinfeng LiDepartment of Anesthesiology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, (The Second Clinical Medical College of Guangzhou University of Chinese Medicine), Guangzhou, 510000, Guangdong, China. lijinfeng@gzucm.edu.cn.
Da GuoState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness, Syndrome of Chinese Medicine, Department of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, 510120, Guangdong, China. david.guo.d@gzucm.edu.cn.
Xing LiState Key Laboratory of Traditional Chinese Medicine Syndrome, State Key Laboratory of Dampness, Syndrome of Chinese Medicine, Department of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, 510120, Guangdong, China. liqixi723@gzucm.edu.cn.

Funding

Natural Science Foundation of China 82104894Natural Science Foundation of Guangdong 2024A1515030293Research Fund for Bajian/Qingmiao Talents of Guangdong Provincial Hospital of Chinese Medicine BJ2022KY07the Research Project of Traditional Chinese Medicine Bureau of Guangdong Province 20231138the Science and Technology Program of Guangzhou 2023A03J0239The Science and Technology Program of Guangzhou 2024A03J0105University - Hospital Joint Fund Project of Guangzhou University of Chinese Medicine GZYZS2024D03
6 · The paper itself

Abstract

Spinal cord injury (SCI), a prevalent cause of severe disability, primarily stems from trauma, degenerative pathologies, or underlying diseases. Spinal cord injury presents significant therapeutic challenges. This study investigated the potential synergistic effect of combining Sodium Tanshinone IIA Sulfonate (STS) and bone mesenchymal stem cell-derived exosomes (BMSC-Exos) for SCI treatment, focusing on the vascular endothelial growth factor (VEGF) pathway.The STS-Exo combination significantly protected Mouse Brain Microvascular Endothelial Cells (bEnd.3) against H

Indexed as

ExosomesMesenchymal Stem CellsPhenanthrenesSignal TransductionSpinal Cord InjuriesVascular Endothelial Growth Factor AAnimalsCell MovementEndothelial CellsHydrogen PeroxideMaleMiceRatsRats, Sprague-DawleyRecovery of FunctionHydrogen PeroxidePhenanthrenestanshinone II A sodium sulfonateVascular Endothelial Growth Factor ABone mesenchymal stem cell-derived exosomes (BMSC-Exos)Sodium tanshinone IIA sulfonate (STS)Spinal cord injury (SCI)Vascular endothelial growth factor pathway (VEGF)

Identifiers

PMID41206417
PMCPMC12596365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.