Evidence map›Paper›PMID 41206326›Full record

ArticleInternational psychogeriatrics2025

Cognitive functioning predicts vulnerability to financial exploitation in APOE e4 carriers.

Gali H Weissberger, Hussein N Yassine, Jenna Axelrod, Laura Fenton, Daisy T Noriega-Makarskyy, Cassidy Molinare, Jordan T Williams, Emma Oyen, Paige Kim, Mark H C Lai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International psychogeriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gali H WeissbergerDepartment of Social and Health Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel. Electronic address: gali.weissberger@biu.ac.il.
Hussein N YassineDepartment of Neurology, Keck School of Medicine of USC, 1975 Zonal Ave., Los Angeles, CA 90023, USA. Electronic address: hyassine@usc.edu.
Jenna AxelrodDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: jennaaxe@usc.edu.
Laura FentonDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: lefenton@usc.edu.
Daisy T Noriega-MakarskyyDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: dnoriega@usc.edu.
Cassidy MolinareDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: molinare@usc.edu.
Jordan T WilliamsDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: jordantw@usc.edu.
Emma OyenDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: oyen@usc.edu.
Paige KimDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: ptkim@usc.edu.
Mark H C LaiDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: hokchiol@usc.edu.
S Duke HanDepartment of Psychology, USC Dornsife College of Letters, Arts, and Sciences, 3551 Trousdale Parkway, Los Angeles, CA 90089, USA. Electronic address: dukehan@usc.edu.

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LON S SCHNEIDER · 2020 to 2026
$27.8M
Establishing the science behind Alzheimer's recruitment registries: opportunities for increasing diversity and accelerating enrollment into trialsR01AG063954 · NIA · BANNER HEALTH · PI BLEAKLEY, AMY, LANGBAUM, JESSICA BROOKE · 2019 to 2023
$9.6M
Finance, Cognition, and Default Network in Aging (FCDNA)R01AG068166 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAN, DUKE · 2024 to 2025
$1.4M
Mid-Career Development and Mentoring on Financial Vulnerability and Alzheimer's DiseaseK24AG081325 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUKE HAN · 2023 to 2026
$798k
NIA NIH HHS K24 AG081325NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG063954NIA NIH HHS R01 AG068166
6 · The paper itself

Abstract

An emerging body of work suggests that financial exploitation vulnerability (FEV) may be an early marker of Alzheimer's disease (AD). We examined how APOE e4 genotype and cognition at baseline interact to predict subsequent FEV one year later. Participants were 95 older adults without dementia aged 50 or older (M age = 69.09, SD = 7.51; 72.63 % female; 72.63 % White non-Hispanic). Participants completed two annual assessments that included comprehensive neuropsychological testing and a measure of FEV. Saliva samples for APOE genotyping were collected. Linear regression models regressed Year 2 FEV on APOE, global cognition, and their interaction. Age, sex, education, and Year 1 FEV scores were covaried. Models were re-run considering cognitive domains separately (memory, language, and attention/working memory and executive functioning). Main effects of APOE and cognition were not found. However, cognition and APOE status interacted to predict Year 2 FEV. Specifically, worse cognitive functioning predicted higher FEV only for e4 carriers. Cognitive domain analyses revealed more nuanced relationships. Findings suggest that cognition is a relevant risk factor of FEV for e4 carriers, and support the emerging idea that FEV may be an early marker of AD-related neuropathological changes.

Indexed as

Alzheimer’s diseaseAPOEFinancial exploitationFraudScams

Identifiers

PMID41206326
PMCPMC12711538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.