ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026
Salidroside ameliorates experimental autoimmune neuritis by dually modulating neuroinflammation and immune homeostasis via PI3K/AKT signaling.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Nanomedicine against oxaliplatin-induced peripheral neuropathy: hypotheses and research perspectives on ion channels and immune microenvironment.Journal of the Egyptian National Cancer Institute · 2026Review
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Abstract
Guillain-Barré syndrome (GBS), an acute autoimmune peripheral neuritis, remains a clinical challenge due to limited therapeutic efficacy and heterogeneous patient responses. The present study investigated salidroside (SAL), a bioactive phenylethanoid glycoside derived from Rhodiola rosea, for its dual anti-inflammatory and neuroprotective properties using experimental autoimmune neuritis (EAN), a validated GBS model. Integrated network pharmacology and molecular docking analyses identified PI3K/AKT signaling as the principal mechanistic target of SAL. In vivo administration of SAL (100 mg/kg/day, intragastric) significantly reduced neurological deficits, alleviated histopathological damage in sciatic nerves, and restored Th1/Th17-Treg immune balance in EAN rats. Mechanistic analysis demonstrated that SAL inhibited NF-κB activation through inhibition of IκBα degradation and p65 nuclear translocation, leading to downregulation of pro-inflammatory cytokines (TNF-α). Concurrently, SAL promoted macrophage polarization from the pro-inflammatory M1 (CD86
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