Evidence map›Paper›PMID 41205872›Full record

ReviewTransplantation and cellular therapy2026

A Practical Guide to Competing Risk Analysis for Transplant and Cell Therapy Research.

Héctor A Vaquera-Alfaro, Yein Jeon, Qian Vicky Wu, Emily C Liang, Andrew Portuguese, Andrés Gómez-De León, Jorge Valdespino-Valdes, Jordan Gauthier

Abstract readReview
In one paragraph

Review in Transplantation and cellular therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Héctor A Vaquera-AlfaroServicio de Hematología, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Yein JeonFred Hutchinson Cancer Center, Clinical Research Division, Seattle, Washington; Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington.
Qian Vicky WuFred Hutchinson Cancer Center, Clinical Research Division, Seattle, Washington.
Emily C LiangFred Hutchinson Cancer Center, Clinical Research Division, Seattle, Washington; Division of Hematology and Oncology, University of Washington, Seattle, Washington.
Andrew PortugueseFred Hutchinson Cancer Center, Clinical Research Division, Seattle, Washington; Division of Hematology and Oncology, University of Washington, Seattle, Washington.
Andrés Gómez-De LeónServicio de Hematología, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Jorge Valdespino-ValdesServicio de Hematología, Hospital Universitario "Dr. José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, México.
Jordan GauthierFred Hutchinson Cancer Center, Clinical Research Division, Seattle, Washington; Division of Hematology and Oncology, University of Washington, Seattle, Washington. Electronic address: jgauthier@fredhutch.org.

Funding

RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
NHLBI NIH HHS T32 HL007093
6 · The paper itself

Abstract

Competing risks are common in hematopoietic cell transplantation (HCT) and immune effector cell (IEC) therapy research. Competing risks refer to events that cannot co-occur and complicate time-to-event analyses. The typical example of competing risk in the context of HCT and IEC research is treatment-related mortality, which competes with disease relapse. In this primer, we first aim to introduce - in a clinician-friendly fashion - the core concepts underlying the statistical modelling of competing risks. Next, we propose a practical, step-by-step guide to analyze time-to-event outcomes in the context of competing risks using the open access R environment. Relevant R packages are introduced, enabling the generation of publication-ready tables and figures. We hope our manuscript will encourage more robust analyses in the fields of HCT and IEC therapy when competing risks are at play.

Indexed as

Cell- and Tissue-Based TherapyHematopoietic Stem Cell TransplantationHumansRisk AssessmentCompeting risks analysisCumulative incidenceHematopoietic cell transplantImmune-effector cell therapyRStudio

Identifiers

PMID41205872
PMCPMC12818700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.