Evidence map›Paper›PMID 41205594›Full record

ArticleCell reports. Medicine2025

Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS.

Shima Shahbaz, Mohammed Osman, Hussain Syed, Andrew Mason, Rhonda J Rosychuk, Jan Willem Cohen Tervaert, Shokrollah Elahi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Prevalence of Long COVID inJournal of clinical tuberculosis and other mycobacterial diseases · 2026
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Trends in long COVID among US adults, 2022-2024.Frontiers in public health · 2026
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shima ShahbazMike Petryk School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Mohammed OsmanDepartment of Medicine, Division of Rheumatology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Hussain SyedDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Andrew MasonDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Rhonda J RosychukDepartment of Pediatrics, Division of Infectious Disease, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Jan Willem Cohen TervaertDepartment of Medicine, Division of Rheumatology, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Shokrollah ElahiMike Petryk School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB T6G 2E1, Canada; Women and Children Health Research Institute, University of Alberta, Edmonton, AB T6G 2E1, Canada; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada; Glycomics Institute of Alberta, University of Alberta, Edmonton, AB T6G 2E1, Canada; Alberta Transplant Institute, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB T6G 2E1, Canada. Electronic address: elahi@ualberta.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long COVID (LC) manifests with sex-specific differences, particularly in those with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study reveals that female LC patients (LCF) with ME/CFS show a shift toward myelopoiesis, reduced lymphocytes, increased neutrophils/monocytes, and depleted regulatory T cells-suggesting persistent immune activation. Elevated CD71

Indexed as

COVID-19Fatigue Syndrome, ChronicTranscriptomeAdultBiomarkersCytokinesFemaleGene Expression ProfilingHumansInflammationMaleMiddle AgedSARS-CoV-2Sex CharacteristicsSex FactorsBiomarkersCytokinesarteminchronic fatigue syndromecortisolerythropoiesisgalectin-9growth hormonelong COVIDReelinsex-related differencestestosterone

Identifiers

PMID41205594
PMCPMC12711683

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.