Evidence map›Paper›PMID 41205412›Full record

ArticleRedox biology2025

Niacin enhances hematoma clearance and neurological recovery via the HCAR2/SIRT1/Nrf2 pathway after germinal matrix hemorrhage.

Xiong Liu, Cheng Cao, Ningbo Xu, Feng Xu, Lei Huang, Prativa Sherchan, Desislava Met Doycheva, John H Zhang, Jiping Tang, Jerry J Flores and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiong LiuDepartment of Emergency Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.
Cheng CaoDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA; Department of Intensive Care Unit, The Affiliated Jiangyin Hospital of Nantong University, Jiangyin, Jiangsu, 214400, China; Department of Brain Center, The Affiliated Jiangyin Hospital of Nantong University, Jiangyin, Jiangsu, 214400, China.
Ningbo XuDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA; Department of Interventional Therapy, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China.
Feng XuDepartment of Emergency Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China.
Lei HuangDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
Prativa SherchanDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.
Desislava Met DoychevaDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA.
John H ZhangDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA; Department of Anesthesiology and Neurology, Loma Linda University School of Medicine, Loma Linda, CA, 92354, USA.
Jiping TangDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. Electronic address: jtang@llu.edu.
Jerry J FloresDepartment of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. Electronic address: jeflores@llu.edu.
Xionghui ChenDepartment of Emergency Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China; Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA, 92354, USA. Electronic address: xhchen@suda.edu.cn.

Funding

Harnessing blood clot clearance mechanisms after germinal matrix hemorrhageR01NS117364 · NINDS · LOMA LINDA UNIVERSITY · PI TANG, JIPING · 2021 to 2025
$2.0M
NINDS NIH HHS R01 NS117364
6 · The paper itself

Abstract

Germinal matrix hemorrhage (GMH) is a common form of neonatal stroke in preterm infants and often results in severe and lasting neurological deficits. Persistent hematoma is a key contributor to secondary brain injury. In this study, we investigated the therapeutic potential of niacin in promoting hematoma clearance and neuroprotection after GMH. We found that intranasal administration of niacin markedly improved neurological function, accelerated hematoma clearance, and attenuated secondary brain damage in neonatal rats. Mechanistically, niacin activated HCAR2(hydroxycarboxylic acid receptor 2) and further upregulated its expression, inducing microglial polarization toward the M2 phenotype through the SIRT1/Nrf2 pathway. This activation enhanced CD36/CD163/HO-1-mediated phagocytosis and degradation of erythrocytes and hemoglobin. Nuclear translocation of Nrf2 is essential for the effects of niacin. CRISPR-mediated knockout of HCAR2, or pharmacological inhibition of SIRT1 or Nrf2, abolished niacin-induced hematoma clearance and neuroprotection. Furthermore, microglial depletion significantly attenuated the protective effects of niacin. Collectively, niacin regulates microglial function via the HCAR2/SIRT1/Nrf2 signaling axis to reduce neuronal damage, neuroinflammation, and oxidative stress, thereby alleviating hydrocephalus and improving neurological outcomes. These findings suggest a potential non-invasive therapeutic strategy for neonatal GMH.

Indexed as

Cerebral HemorrhageHematomaNF-E2-Related Factor 2NiacinSignal TransductionSirtuin 1AnimalsDisease Models, AnimalHumansMaleMicrogliaRatsNfe2l2 protein, ratNF-E2-Related Factor 2NiacinSirt1 protein, ratSirtuin 1Germinal matrix hemorrhage (GMH)HCAR2(hydroxycarboxylic acid receptor 2)HematomaMicrogliaNeurological functionNiacin

Identifiers

PMID41205412
PMCPMC12793745

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.