Evidence map›Paper›PMID 41205213›Full record

ArticleChemistry & biodiversity2026

Chemical Profiles and Bioactivities of Brazilian Amazonian Solanum Species: Antioxidant, Cytotoxic, and Anti-Metastatic Properties.

Juliana C Atherino, Eduarda C Amaral, Gustavo T Corrêa, Fábio S Murakami, Leandro L Giacomin, Leopoldo C Baratto, Lauro M de Souza, Thalita G Santos, Wesley M de Souza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juliana C AtherinoLaboratory of Bacteriology, Mycology and Cell Biology, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0001-8262-2521
Eduarda C AmaralPequeno Principe College, Pelé Pequeno Principe Research Institute, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-8217-8907
Gustavo T CorrêaLaboratory of Pharmacognosy, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0009-0004-2987-4147
Fábio S MurakamiQuality Control Laboratory II, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-6238-3604
Leandro L GiacominLaboratory of Plant Physiology and Evolution, Department of Systematics and Ecology, Center for Exact and Natural Sciences, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0001-8862-4042
Leopoldo C BarattoLaboratory of Applied Pharmacognosy, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-7125-7431
Lauro M de SouzaPequeno Principe College, Pelé Pequeno Principe Research Institute, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0001-9166-2146
Thalita G SantosLaboratory of Pharmacognosy, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0002-0007-4750
Wesley M de SouzaLaboratory of Bacteriology, Mycology and Cell Biology, Federal University of Paraná, Curitiba, Paraná, Brazil.ORCID https://orcid.org/0000-0001-7918-7936

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408914/2023-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 422191/2021-3Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
6 · The paper itself

Abstract

This study investigated the chemical and biological properties of hydroethanolic extracts from Solanum asperum, Solanum crinitum, Solanum schlechtendalianum, Solanum stramoniifolium, and Solanum leucocarpon. Using ultra-high-performance liquid chromatography with electrospray ionization mass spectrometry and gas chromatography, 41 compounds and five monosaccharides were identified. Antioxidant activity was confirmed in all extracts through the DPPH radical scavenging assay, with S. schlechtendalianum showing the highest activity, consistent with its elevated total polyphenol (94.4 mg GAE/g) and flavonoid (46.8 mg QE/g) contents. The anticancer potential was assessed against human breast (MCF-7, MDA-MB-231) and colorectal (HRT-18) cancer cell lines using the MTT assay. Among the samples, S. crinitum exhibited the greatest cytotoxicity against HRT-18 cells, with an IC

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsPlant ExtractsSolanumBiphenyl CompoundsBrazilCell Line, TumorCell MovementCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansNitric OxidePicratesStructure-Activity RelationshipAntineoplastic Agents, PhytogenicAntioxidantsBiphenyl CompoundsNitric OxidePicratesPlant ExtractsantioxidantscancercytotoxicitymetastasisSolanum

Identifiers

PMID41205213
PMCPMC13421947

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.