Evidence map›Paper›PMID 41205187›Full record

ReviewChemistry, an Asian journal2025

Synthetic Methods for Four-Membered Carbocycles Bearing Emerging Fluorinated Motifs.

Hikaru Yanai, Shoki Hoshikawa, Kentaro Kawai, Takashi Matsumoto

Abstract readReview
In one paragraph

Review in Chemistry, an Asian journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hikaru YanaiSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.
Shoki HoshikawaFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Kentaro KawaiFaculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka, Japan.
Takashi MatsumotoSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan.

Funding

Grant-in-Aid for Scientific Research (C) JSPS 23K06031Takeda Science Foundation
6 · The paper itself

Abstract

The unique conformational properties of four-membered carbocycles (cyclobutanes and cyclobutenes) have attracted attention in drug design. Meanwhile, fluorine and various fluorine-containing groups are essential substituents in the development of biologically active agents. The combination of the four-membered carbocycle with fluorinated motifs represents a promising approach. This review focuses on synthetic methods for four-membered carbocycles bearing some emerging fluorine-containing substituents, particularly fluoroalkyl, and sulfur-linked fluorinated functionalities.

Indexed as

cyclizationcycloadditionfluorinesmall ring systemssynthetic methods

Identifiers

PMID41205187
PMCPMC12696810

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.