Evidence map›Paper›PMID 41205137›Full record

ArticleGlycoconjugate journal2025

In Silico and in vitro evaluation of Cucurbitaceae seed lectins as promising prophylactic and therapeutic agents against SARS-CoV-2.

Rumana Ahmad, Yusuf Akhter, Varsha, Tanveer Ahamad, Aditi Srivastava, Kusum Yadav, Sahabjada Siddiqui, D Himanshu Reddy, Ankita Gupta, Yashi Nigam and 4 more

Abstract read
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Article in Glycoconjugate journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rumana AhmadDept. of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India. rumana_ahmad@yahoo.co.in.
Yusuf AkhterDept. of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, UP, India.
VarshaDept. of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, 226025, UP, India.
Tanveer AhamadDept. of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
Aditi SrivastavaDept. of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
Kusum YadavDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, UP, India. anukusum@gmail.com.
Sahabjada SiddiquiDept. of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
D Himanshu ReddyDepartment of Internal Medicine, King George's Medical University, Lucknow, 226003, UP, India.
Ankita GuptaDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, UP, India.
Yashi NigamDept. of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
Mohammad Amir KhanDept. of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
Ishrat HusainDept. of Biochemistry, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003, UP, India.
Shivani MishraDepartment of Biochemistry, University of Lucknow, Lucknow, 226007, UP, India.
Mohsin Ali KhanDepartment of Research & Development, Era University, Lucknow, 226003, UP, India.

Funding

Indian Council of Medical Research ITR/Adhoc/2/2023-24 dated 05/09/2023
6 · The paper itself

Abstract

Concern over COVID-19 has arisen from continuous mutations in SARS-CoV-2 genome leading to emergence of novel variants. A detailed study and understanding of N-linked glycans (NAGs) of SARS-CoV-2 spike protein are key for the development of vaccines and new therapeutic strategies. Potential of four Cucurbitaceae seed lectins (CSLs) to inhibit SARS-CoV-2 attachment to host cells via interaction with receptor binding domain (RBD), was determined by Molecular Docking using PRODIGY and LZerD web servers. Among them, Luffa cylindrica lectin (PDB ID: 1NIO) displayed the most significant binding (B.E.: -24.9 kcal/mol; K

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentCucurbitaceaeLectinsPlant LectinsSARS-CoV-2SeedsSpike Glycoprotein, CoronavirusBinding SitesCOVID-19HumansMolecular Docking SimulationPolysaccharidesProtein BindingAntiviral AgentsLectinsPlant LectinsPolysaccharidesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Antiviral lectinsCucurbitaceae lectinsIn Silico biologyLectin-glycan interactionN-linked glycansPhytohemagglutininsSARS-CoV-2

Identifiers

PMID41205137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.