Evidence map›Paper›PMID 41205012›Full record

ArticleScience China. Life sciences2026

Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β.

Jun Ren, Yiliang Xu, Lin Yuan, Yingxin Liu, Qian Chu, Tian Zhao, Wei Zhang, Jing Tian, Shi-Qiang Wang, Haihong Ye

Abstract read
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In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jun Ren *Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yiliang Xu *Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Lin Yuan *Department of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yingxin LiuDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Qian ChuDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Tian ZhaoDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Wei ZhangDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Jing TianDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Shi-Qiang WangState Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China. wsq@pku.edu.cn.
Haihong YeDepartment of Medical Genetics and Developmental Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. yehaihong@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disrupted-In-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders, encodes a multifunctional protein implicated in various aspects of neuronal development. However, the precise role of DISC1 in neuronal polarization has remained elusive. Here, we show that dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons. Expression of phosphodead human DISC1 (hDISC1

Indexed as

Cerebral CortexGlycogen Synthase Kinase 3 betaNerve Tissue ProteinsNeuronsSerineAnimalsAxonsCells, CulturedGene Knock-In TechniquesHumansMicePhosphorylationSchizophreniaDISC1 protein, humanDisc1 protein, mouseGlycogen Synthase Kinase 3 betaNerve Tissue ProteinsSerineDISC1GSK3βneuronal polarizationphosphorylationschizophrenia

Identifiers

PMID41205012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.