Evidence map›Paper›PMID 41204997›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Correlation of drusen burden and vascular integrity in age-related macular degeneration using three-dimensional choroidal vascular model.

Priyanka Gandhi, Elham Sadeghi, Anne Schulman, Sumit Randhir Singh, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Andrew W Eller, Jay Chhablani

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Priyanka GandhiUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Elham SadeghiUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Anne SchulmanUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Sumit Randhir SinghAkhand Jyoti Eye Hospital, CoE Mastichak, Saran, Bihar, India.
Sandeep Chandra BollepalliUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Kiran Kumar VupparaboinaUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Jose Alain SahelUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Andrew W EllerUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
Jay ChhablaniUniversity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA. jay.chhablani@gmail.com.ORCID http://orcid.org/0000-0003-1772-3558

Funding

Eye and Ear Foundation of Pittsburgh NIH Core Grant P30 EY08098
6 · The paper itself

Abstract

purposeTo study intricate relationship between drusen volume and evolving dynamics of retinal and choroidal vasculature in dry age-related macular degeneration (AMD).

methodsPatients underwent swept-source optical coherence tomography angiography (SS-OCTA) using Plex Elite 9000 device. Retinal thickness, retinal vessel perfusion, drusen volume, choroidal thickness (ChT), choroidal vascularity index (CVI), choroidal vessel diameters (MChVD), and intervessel distance (IVD) were assessed. The Advanced Research and Innovation (ARI) Network, ResUNet model, and Phansalkar thresholding were utilized for image analysis. The linear mixing model was used for the statistical analysis.

resultsWe assessed 53 eyes from 40 patients with dry AMD (22 eyes with early-stage, 31 eyes with intermediate-stage eyes). The mean age was 75.25 years and 62.5% were females. The mean LogMar visual acuity was 0.09 ± 0.17 standard deviation (SD) in early-stage and 0.19 ± 0.14 SD in intermediate-stage (p = 0.03). Mean drusen volume was 0.075 ± 0.125 SD mm

conclusionWith increase in drusen volume, a reduction in CVI and MChVD was noted, without any significant association with changes in retinal metrics, suggesting that choroidal vessels may exhibit early changes during disease progression.

Indexed as

ChoroidFluorescein AngiographyImaging, Three-DimensionalRetinal DrusenRetinal VesselsTomography, Optical CoherenceAgedAged, 80 and overFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedRetrospective StudiesVisual AcuityAMDCVIDrusen volumeMChVD

Identifiers

PMID41204997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.