Evidence map›Paper›PMID 41204986›Full record

ArticleSkeletal radiology2026

Keratin-positive giant cell-rich tumor with HMGA::NCOR2 fusion in a 4-year-old.

Rachel S Lee, Wei Chen, William Eward, Joseph Cao

Abstract readCase Reports
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In one paragraph

Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rachel S LeeDuke University School of Medicine, 40 Duke Medicine Circle, Durham, NC, 27710, USA. Rachel.lee@duke.edu.
Wei ChenDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.
William EwardDepartment of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA.
Joseph CaoDepartment of Radiology, Division of Pediatric Radiology, Duke University Medical Center, Durham, NC, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epiphyseal and metaphyseal bone lesions in pediatric patients are uncommon, and lesions that cross an open physis are even rarer. The differential diagnosis for such lesions consists of infection, giant cell tumor, and chondroblastoma. We describe a 4-year-old male patient who presented with a bone tumor originating in the proximal tibial metaphysis that extended across the physis into the epiphysis. Sampling revealed a HMGA2::NCOR2 fusion associated with a recently described subset of giant cell-rich bone and soft tissue tumors. This case expands the differential diagnosis for cross-physeal and epiphyseal bone tumors in pediatric patients and highlights the radiological features of keratin-positive giant cell-rich tumor (KPGCT).

Indexed as

Bone NeoplasmsGiant Cell Tumor of BoneHMGA2 ProteinChild, PreschoolDiagnosis, DifferentialHumansKeratinsMagnetic Resonance ImagingMaleTibiaHMGA2 ProteinHMGA2 protein, humanKeratinsBone neoplasmsChildChondroblastomaEpiphyseal plateGiant cell tumor of boneHMGA2 protein

Identifiers

PMID41204986

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.