SynthesisCancer reports (Hoboken, N.J.)2025
Diagnostic Test Accuracy of Apparent Diffusion Coefficient in Evaluation of Breast Cancer Lymph Node Metastasis: A Systematic Review and Meta-Analysis.
Synthesis in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Test Accuracy of Apparent Diffusion Coefficient in Evaluation of Breast Cancer Lymph Node Metastasis: A Systematic Review and Meta-Analysis.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Diagnostic Potential of Apparent Diffusion Coefficient-Based Lymph Node Classification in Breast Cancer Patients Undergoing [Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to evaluate the diagnostic accuracy of the apparent diffusion coefficient (ADC) derived from diffusion weighted imaging (DWI) for detecting lymph node metastasis in breast cancer.
methodsA systematic review and meta-analysis was conducted following the PRISMA-DTA guidelines. PubMed, Web of Science, PROQUEST, and EMBASE were searched. ADC values for suspected lymph nodes in breast cancer patients were assessed, with histopathology as the reference test. Data were analyzed using a bivariate meta-analytical model with Meta-DiSc 2.0 and STATA 17. Meta-regression and subgroup analysis were conducted to assess heterogeneity.
resultsTwenty-six studies encompassing 2828 participants were included. The pooled sensitivity and specificity of ADC value for detecting lymph node metastasis were 88.6% (CI = 82.4%-92.8%) and 83.6% (CI = 78.0%-88.1%), respectively. The area under the HSROC curve was 0.92 (CI = 0.89-0.94), indicating excellent diagnostic ability. Moderate heterogeneity was detected (prediction area = 0.369; bivariate I
conclusionADC value is a highly accurate non-invasive diagnostic marker for lymph node metastasis in breast cancer. We recommend acquisition of DWI in women less than 51 years old, with the highest b-value of 1000 s/mm
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