Evidence map›Paper›PMID 41204888›Full record

ReviewEpilepsia2026

Spreading depolarization and its influence on epileptiform activity.

Maxime Lévesque, Rüdiger Köhling, Massimo Avoli

Abstract readReview
In one paragraph

Review in Epilepsia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maxime LévesqueDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Quebec, Canada.ORCID https://orcid.org/0000-0002-1593-7037
Rüdiger KöhlingOscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany.ORCID https://orcid.org/0000-0003-3330-4898
Massimo AvoliDepartment of Neurology & Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Quebec, Canada.

Funding

CIHR MOP130328CIHR PJT153310CIHR PJT166178Savoy Foundation
6 · The paper itself

Abstract

Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K

Indexed as

Cortical Spreading DepressionEpilepsyAnimalsHumansNeuronsictogenesisseizuresspreading depolarizationsudden unexpected death in epilepsy

Identifiers

PMID41204888
PMCPMC13007837

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.