ArticleJournal of child psychology and psychiatry, and allied disciplines2026
Individual differences in effects of stressful life events on childhood ADHD: genetic, neural, and familial contributions.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Predicting ADHD in Children and Adolescents With Artificial Intelligence: A Scoping Review of Common Models.Health science reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThis study elucidates the intricate relationship between stressful life events and the development of ADHD symptoms in children, acknowledging the considerable variability in individual responses. By examining these differences, we aim to uncover the unique combinations of factors contributing to varying levels of vulnerability and resilience among children.
methodsUtilizing longitudinal data from the Adolescent Brain Cognitive Development study (baseline: N = 6,303, age = 9.9), we applied Generalized Random Forest (GRF) to model the nonlinear relationships among genetic predispositions, brain features, and environmental factors.
resultsSignificant individual variability was observed in children's ADHD symptoms post-stress, particularly at the 1-year and 2-year follow-ups. At the 1-year follow-up, increased vulnerability was indicated by heightened parental mental health problems and a lower polygenic risk score for smoking. By the 2-year follow-up, escalated parental mental health disorders, higher ADHD polygenic risk scores (PRS), and altered structural connectivity in the cognitive control network were significant contributors to individual differences.
conclusionsThese findings underscore the importance of integrating environmental, genetic, and neural variables to identify children vulnerable or resilient to developing ADHD symptoms following early-life stress. This study demonstrates how multimodal data combined with nonparametric machine learning can advance precision psychology and psychiatry, aiding targeted support for affected children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.