Evidence map›Paper›PMID 41204827›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2026

A content analysis of health-related epigenetic information in YouTube videos.

Aantaki Raisa, Irania Santaliz Moreno, Amy Ayala, Jada G Hamilton, Jessica Mozersky, Erin Linnenbringer, Julia Maki, Amy McQueen, George P Souroullas, Erika A Waters

Abstract read
In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aantaki RaisaDivision of Public Health Sciences, Washington University in St Louis, MO.
Irania Santaliz MorenoRoy and Diana Vagelos Division of Biology and Biomedical Sciences (DBBS), Washington University in St Louis, St Louis, MO.
Amy AyalaInstitute for Community Health Innovation, University of Arkansas for Medical Sciences, Springdale, AR.
Jada G HamiltonDepartment of Psychiatry and Behavioral Sciences; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Jessica MozerskyBioethics Research Center, Division of General Medicine and Geriatrics, Washington University in St Louis, St Louis, MO.
Erin LinnenbringerDivision of Public Health Sciences, Washington University in St Louis, MO.
Julia MakiDivision of Public Health Sciences, Washington University in St Louis, MO.
Amy McQueenDivision of General Medicine and Geriatrics, Washington University in S Louis, St Louis, MO.
George P SouroullasDepartment of Medicine, Division of Oncology, Washington University in St Louis, St. Louis, MO.
Erika A WatersDivision of Public Health Sciences, Washington University in St Louis, MO. Electronic address: waterse@wustl.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Investigating ELSI issues that may facilitate or impede clinical translation of epigenomic researchR01ES033743 · NIEHS · WASHINGTON UNIVERSITY · PI Erika A Waters · 2022 to 2026
$2.8M
NCI NIH HHS P30 CA008748NIEHS NIH HHS R01 ES033743
6 · The paper itself

Abstract

purposeThis study aimed to explore how health-related epigenetic concepts are depicted in YouTube videos, a widely accessed platform for informal science education. As epigenetics becomes increasingly relevant to medical therapeutics, it is essential to understand what information is being disseminated in the public sphere.

methodsWe conducted a content analysis of 296 YouTube videos about epigenetics that were under 10 minutes in length. We transcribed and analyzed the videos using an iteratively developed codebook and then categorized relevant codes as categories.

resultsWe identified 7 categories: (1) defining epigenetics, (2) causes of epigenetic changes, (3) effects of epigenetic change, (4) epigenetic inheritability, (5) application of epigenetics, (6) personal control, and (7) epigenetic mysticism. Although the content about the molecular epigenetic mechanisms mostly aligned with the latest scientific findings, there were numerous unsubstantiated and exaggerated claims about effects of epigenetics on human health, especially disease outcomes.

conclusionWe identified several scientific concepts described on YouTube regarding epigenetics. Our findings also reveal what information about epigenetics is widely shared in the public sphere, helping to identify key misconceptions to address and guiding the development of strategies for accurate scientific communication.

Indexed as

Epigenesis, GeneticEpigenomicsSocial MediaVideo RecordingHumansInformation DisseminationContent analysisEpigenetic communicationEpigeneticsHealth communicationSocial mediaYouTube

Identifiers

PMID41204827
PMCPMC13077652

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.