Evidence map›Paper›PMID 41204768›Full record

ArticleThe New phytologist2026

Arabidopsis phospholipid modifications mediate cellulase-induced resistance to a fungal peptide antibiotic by imposing cell polarity.

Saritha Panthapulakkal Narayanan, Bradley R Dotson, Lise Noack, Sanjana Holla, Shichao Ren, Peter Dörmann, Susanne Widell, Staffan Persson, Ida Lager, Allan G Rasmusson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saritha Panthapulakkal NarayananDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.
Bradley R DotsonDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.
Lise NoackCopenhagen Plant Science Center (CPSC), Department of Plant & Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.
Sanjana HollaDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.
Shichao RenDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.
Peter DörmannInstitute of Molecular Physiology and Biotechnology of Plants, University of Bonn, Karlrobert-Kreiten-Strasse 13, 53115, Bonn, Germany.ORCID https://orcid.org/0000-0002-5845-9370
Susanne WidellDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.
Staffan PerssonCopenhagen Plant Science Center (CPSC), Department of Plant & Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.ORCID https://orcid.org/0000-0002-6377-5132
Ida LagerDepartment of Plant Breeding, Swedish University of Agricultural Sciences, SE-234 22, Lomma, Sweden.
Allan G RasmussonDepartment of Biology, Lund University, Biology Building, Sölvegatan 35B, SE-223 62, Lund, Sweden.ORCID https://orcid.org/0000-0003-0734-5020

Funding

Carl Tryggers Stiftelse för Vetenskaplig Forskning CTS 2019:295SLU Grogrund funding 2020.4.3 651Sven och Lilly Lawskis Fond för Naturvetenskaplig ForskningSwedish Research Council Vetenskapsrådet 2020-05417
6 · The paper itself

Abstract

Plant-symbiotic Trichoderma fungi attack microorganisms by secreting antibiotic membrane-permeabilising peptaibols such as alamethicin. These peptaibols also permeabilise plant root epidermis plasma membranes (PMs), but mild pretreatment with Trichoderma cellulase activates a unique cellulase-induced resistance to alamethicin (CIRA), via an unknown mechanism. We identify two Arabidopsis genes that are essential for the CIRA process: CIRA12 encodes a phosphatidylserine (PS) decarboxylase and CIRA13, a phospholipase Dζ, implying that specific changes in anionic membrane lipids mediate alamethicin resistance. Fluorescent sensors revealed that cellulase induced a laterally asymmetric decrease in PS and surface charge to outer periclinal root epidermal PMs. Consistently, the CIRA response was reversed by addition of lysoPS. CIRA13 is essential for vesicle trafficking, which in turn is crucial for CIRA induction. Overall, cellulase induces a cellular polarity with respect to phospholipids, not previously observed in plants, that is leading to increased lipid packing and preventing peptaibol permeabilization of the outer periclinal membrane.

Indexed as

AlamethicinAnti-Bacterial AgentsArabidopsisCell PolarityCellulasePeptidesPhospholipidsArabidopsis ProteinsCell MembranePlant EpidermisPlant RootsAlamethicinAnti-Bacterial AgentsArabidopsis ProteinsCellulasePeptidesPhospholipidsalamethicinArabidopsiscellulasephosphatidic acidphosphatidylserinePHOSPHATIDYLSERINE DECARBOXYLASE3PHOSPHOLIPASE Dζ2Trichoderma

Identifiers

PMID41204768
PMCPMC12712430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.